Dexamethasone Versus Placebo in Optimizing the Postoperative Period After Laparoscopic Inguinal Hernia Repair

Dexamethasone Versus Placebo in Optimizing the Postoperative Period After Laparoscopic Inguinal Hernia Repair

Does corticosteroid (dexamethasone) have an effect on the postoperative period after laparoscopic hernia repair, when it comes to pain, postoperative nausea and vomiting and convalescence. This randomized, double-blinded study compares dexamethasone versus placebo. The patients are recommended one day of convalescence. The medicine or placebo is given before operation. The patients fill out questionnaire before operation and three hours after operation and in the following three days. The patients also register when they return to normal activities and work.

Inclusion Criteria:

• patients planned for elective laparoscopic hernia repair (TAPP)
• Unilateral inguinal or femoral hernia
• ASA class I-II
• Read and speak Danish

Exclusion Criteria:

• Acute hernia operation
• Operation for other hernias with mesh during the same procedure
• Endocrine disease (diabetes, adrenal insufficiency etc.)
• fever/infection within the first 10 days before operation
• Poor compliance
• No signed consent form
• Daily intake of opioids or anxiolytic drugs
• Manic episodes
• Use medicine against glaucoma
• Use thiazide or loop diuretics
• Vaccination within the last 14 days