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| Name | Class |
|---|---|
| Inje University | OTHER |
The genetic polymorphisms of the cytochrome P450 may influence on the metabolism of tamoxifen.
The investigators want to
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Breast cancer patients | Breast cancer patients who underwent surgery with or without chemotherapy, endocrine therapy and/or radiation therapy. The patients are categorized according to the genetic polymorphisms or the activity score of the cytochrome P450 metabolism. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| tamoxifen | Drug |
|
| Measure | Description | Time Frame |
|---|---|---|
| The frequency of the genetic polymorphisms of CYP2D6 in breast cancer patients | ||
| The frequency of the genetic polymorphisms of CYP3A4/5 in breast cancer patients | ||
| The frequency of the genetic polymorphisms of CYP2C19 in breast cancer patients |
| Measure | Description | Time Frame |
|---|---|---|
| The association between the genetic polymorphisms of CYP2D6 and outcomes in breast cancer patients with tamoxifen therapy | ||
| The association between the genetic polymorphisms of CYP3A4/5 and outcomes in breast cancer patients with tamoxifen therapy |
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Inclusion Criteria:
Exclusion Criteria:
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Breast cancer survivors who underwent surgery at Severance hospital, Yonsei University Health System.
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| Name | Affiliation | Role |
|---|---|---|
| Byeong-Woo Park, M.D.,ph.D. | Department of Surgery and Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine | Study Chair |
| Jae-Gook Shin, M.D.,ph.D. | Department of Pharmacology and Pharmacogenomics Research Center, Inje University College of Medicine | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Pharmacology and Pharmacogenomics Research Center, Inje University College of Medicine | Jin-Gu | Busan | , 614-735 | South Korea |
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| ID | Term |
|---|---|
| D001943 | Breast Neoplasms |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D001941 | Breast Diseases |
| D012871 | Skin Diseases |
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| ID | Term |
|---|---|
| D013629 | Tamoxifen |
| ID | Term |
|---|---|
| D013267 | Stilbenes |
| D001597 | Benzylidene Compounds |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
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Blood samples with DNA
| The association between the genetic polymorphisms of CYP2C19 and outcomes in breast cancer patients with tamoxifen therapy |
| Department of Surgery, Yonsei University College of Medicine | Saedaemoon-gu | Seoul | 120-752 | South Korea |
| D017437 |
| Skin and Connective Tissue Diseases |
| D006844 |
| Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |