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The purpose of this prospective, participant-blinded trial is to determine the changes in sleep architecture in a cohort of subjects who have undergone deep brain stimulation (DBS) surgery for treatment of movement disorders such as moderate to advanced Parkinson's disease (PD), tremor, or dystonia. Our preliminary observational data suggest that unilateral subthalamic nucleus (STN) DBS improves subjective sleep quality in PD patients 6 months after the procedure. The cause of this improvement in sleep quality is unknown, and this study proposes the use of polysomnography (PSG) to test whether the improvement in sleep is independent of improvement in night-time mobility associated with DBS treatment of the motor symptoms of PD, tremor, or dystonia.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| DBS on | Experimental | baseline settings |
|
| DBS off | No Intervention | DBS off |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Alteration of DBS stimulator settings | Other | Alteration of DBS stimulator settings |
|
| Measure | Description | Time Frame |
|---|---|---|
| Sleep Efficiency | This is the percentage of time the subject is in bed when he/she is actually asleep. | 1 month |
| Measure | Description | Time Frame |
|---|---|---|
| Wake after sleep onset (WASO) | This is a measurement of the amount of time during polysomnography recording that the subject is awake after their initial sleep onset. | 1 month |
| Total Sleep Time |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Amy W Amara, MD, phD | UAB Neurology | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35294 | United States |
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| ID | Term |
|---|---|
| D010300 | Parkinson Disease |
| D014202 | Tremor |
| D004421 | Dystonia |
| ID | Term |
|---|---|
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| 1 month |
| Two timed motor tasks |
| 1 month |
| D009422 | Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |
| D020820 | Dyskinesias |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |