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Cannabis use by people with schizophrenia is associated with family distress and poor clinical outcomes. Therefore, an Family Motivational Intervention (FMI) was developed to help parents to motivate their child with a diagnoses of recent-onset schizophrenia to reduce cannabis use.
In a single-blind randomised clinical trail with 75 patients with the diagnosis of schizophrenia, parents will be assigned to either FMI or to routine care. Assessments will be conducted at baseline and at a 10- and 22-month follow-up. The study hypothesis is that FMI will be more effective than routine care in reducing (a) cannabis use in patients and (b) distress and sense of burden in parents.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Family Motivational Intervention | Experimental | An intervention provided to parents consisting of 6 sessions of training in Interactions Skills and 6 sessions training in Motivational Interviewing. |
|
| Routine care for parents | Active Comparator | Routine care for parents consisting of 2 sessions psycho-education and individual support |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Family Motivational Intervention | Behavioral | A intervention with provided parents 6 sessions of Interaction Skills training and 6 sessions Motivational Interviewing training. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Cannabis use in patients with a diagnosis of recent-onset schizophrenia | Baseline (before the start of the intervention) | |
| Cannabis use in patients with a diagnosis of recent-onset schizophrenia | 10-month follow-up (3 months after the intervention has ended) | |
| Cannabis use in patients with a diagnosis of recent-onset schizophrenia | 22-month follow-up (15 months after the intervention has ended) |
| Measure | Description | Time Frame |
|---|---|---|
| Medication adherence in patients with a diagnosis of recent-onset schizophrenia | Baseline (before the start of the intervention) | |
| Medication adherence in patients with a diagnosis of recent-onset schizophrenia | 10-month follow-up (3 months after the intervention has ended) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Gerard Schippers, Prof. dr. | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Study Director |
| Don Linszen, Prof.dr. | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Principal Investigator |
| Lieuwe de Haan, Dr. | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Academic Medical Center | Amsterdam | North Holland | 1066 DP | Netherlands |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19917142 | Background | Dekker N, Smeerdijk AM, Wiers RW, Duits JH, van Gelder G, Houben K, Schippers G, Linszen DH, de Haan L. Implicit and explicit affective associations towards cannabis use in patients with recent-onset schizophrenia and healthy controls. Psychol Med. 2010 Aug;40(8):1325-36. doi: 10.1017/S0033291709991814. Epub 2009 Nov 17. |
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| ID | Term |
|---|---|
| D002189 | Marijuana Abuse |
| D012559 | Schizophrenia |
| ID | Term |
|---|---|
| D019966 | Substance-Related Disorders |
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |
| D019967 | Schizophrenia Spectrum and Other Psychotic Disorders |
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| Medication adherence in patients with a diagnosis of recent-onset schizophrenia | 22-month follow-up (15 months after the intervention has ended) |
| Quality of life in patients with recent-onset schizophrenia | Baseline (before the start of the intervention) |
| Quality of life in patients with recent-onset schizophrenia | 10-month follow-up (3 months after the intervention has ended) |
| Quality of life in patients with recent-onset schizophrenia | 22-month follow-up (15 months after the intervention has ended) |
| Stress in parents due to caring for a child with recent-onset schizophrenia | Baseline (before the start of the intervention) |
| Stress in parents due to caring for a child with recent-onset schizophrenia | 10-month follow-up (3 months after the intervention has ended) |
| Stress in parents due to caring for a child with recent-onset schizophrenia | 22-month follow-up (15 months after the intervention has ended) |
| Expressed emotion in parents of patients with recent-onset schizophrenia | Baseline (before the start of the intervention) |
| Expressed emotion in parents of patients with recent-onset schizophrenia | 10-month follow-up (3 months after the intervention has ended) |
| Expressed emotion in parents of patients with recent-onset schizophrenia | 22-month follow-up (15 months after the intervention has ended) |