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The aim of this study is to investigate the change in iron metabolism in relation to malaria and helminth infections using a stable isotope technique.
The aim of the study is to determine how iron metabolism in subjects with infectious diseases (malaria, hookworm or S. haematobium) differs while infected and after treatment, i.e. the same individuals will be restudied while free of infection.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Symptomatic malaria infection | Other |
| |
| Asymptomatic malaria infection | Other |
| |
| Hookworm infection | Other |
| |
| Schistosoma haematobium infection | Other |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Fe-57 orally, Fe-58 intravenously | Dietary Supplement | Subjects will receive a test drink containing 3 mg Fe-57 in the form of labelled FeSO4 followed by 1 ml of an aqueous solution containing 50 μg Fe-58 as iron citrate. |
| Measure | Description | Time Frame |
|---|---|---|
| Isotope absorption into blood stream | Day 15 | |
| Isotope absorption into blood stream | Day 43 |
| Measure | Description | Time Frame |
|---|---|---|
| Isotope incorporation into erythrocytes | Day 15 | |
| Biochemical parameters of iron status and infection | Day 1 | |
| Biochemical parameters of iron status and infection |
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Inclusion Criteria:
Exclusion Criteria:
-
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| Name | Affiliation | Role |
|---|---|---|
| Rita Wegmüller, Dr. | Swiss Federal Institute of Technology (ETH) Zurich | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Taabo Cité Hospital | Taabo | Côte d’Ivoire |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 20107144 | Background | Rohner F, Zimmermann MB, Amon RJ, Vounatsou P, Tschannen AB, N'goran EK, Nindjin C, Cacou MC, Te-Bonle MD, Aka H, Sess DE, Utzinger J, Hurrell RF. In a randomized controlled trial of iron fortification, anthelmintic treatment, and intermittent preventive treatment of malaria for anemia control in Ivorian children, only anthelmintic treatment shows modest benefit. J Nutr. 2010 Mar;140(3):635-41. doi: 10.3945/jn.109.114256. Epub 2010 Jan 27. | |
| 16772442 |
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| ID | Term |
|---|---|
| D016778 | Malaria, Falciparum |
| D006725 | Hookworm Infections |
| D012553 | Schistosomiasis haematobia |
| D008288 | Malaria |
| ID | Term |
|---|---|
| D011528 | Protozoan Infections |
| D010272 | Parasitic Diseases |
| D007239 | Infections |
| D000096724 | Mosquito-Borne Diseases |
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| Day 15 |
| Biochemical parameters of iron status and infection | Day 29 |
| Biochemical parameters of iron status and infection | Day 43 |
| Isotope incorporation into erythrocytes | Day 43 |
| Background |
| Wegmuller R, Camara F, Zimmermann MB, Adou P, Hurrell RF. Salt dual-fortified with iodine and micronized ground ferric pyrophosphate affects iron status but not hemoglobin in children in Cote d'Ivoire. J Nutr. 2006 Jul;136(7):1814-20. doi: 10.1093/jn/136.7.1814. |
| 8172870 | Background | Kastenmayer P, Davidsson L, Galan P, Cherouvrier F, Hercberg S, Hurrell RF. A double stable isotope technique for measuring iron absorption in infants. Br J Nutr. 1994 Mar;71(3):411-24. doi: 10.1079/bjn19940148. |
| Background | Walczyk T, Davidsson L, Zavaleta N, Hurrell RF. Stable isotope labels as a tool to determine the iron absorption by Peruvian school children from a breakfast meal. Fresenius Journal of Analytical Chemistry 359: 445-449, 1997. |
| 25733630 | Derived | Glinz D, Hurrell RF, Righetti AA, Zeder C, Adiossan LG, Tjalsma H, Utzinger J, Zimmermann MB, N'Goran EK, Wegmuller R. In Ivorian school-age children, infection with hookworm does not reduce dietary iron absorption or systemic iron utilization, whereas afebrile Plasmodium falciparum infection reduces iron absorption by half. Am J Clin Nutr. 2015 Mar;101(3):462-70. doi: 10.3945/ajcn.114.090175. Epub 2015 Feb 4. |
| D000079426 |
| Vector Borne Diseases |
| D017206 | Strongylida Infections |
| D017190 | Secernentea Infections |
| D009349 | Nematode Infections |
| D006373 | Helminthiasis |
| D012552 | Schistosomiasis |
| D014201 | Trematode Infections |
| D014552 | Urinary Tract Infections |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |