Recovery Effect of Sugammadex Measured by Bispectral and Neurosense Indices

Pilot Study of EEG Signs of Awakening Secondary to Injection of Sugammadex: Evaluation by Recording Bispectral Index and NeuroSENSE (Prospective, Double-blind Study)

It has been demonstrated that antagonism of neuromuscular blockade (neostigmine 0.04 mg kg-1) affects depth of anaesthesia with an increase in bispectral index (mean maximal change of 7.1) and middle-latency auditory evoked potentials (mean maximal change of 9.7).

Sugammadex has a quicker and more complete effect than neostigmine. This study aims to demonstrate if sugammadex administration increases bispectral and neurosense indices of the depth of anesthesia while patients still receive propofol-remifentanil iv anesthesia.

Inclusion Criteria:

• patients scheduled to receive general anesthesia with muscle relaxation

Exclusion Criteria:

• contra-indication to the administration of propofol, remifentanil, rocuronium and to the use of the Bispectral Index or NeuroSense monitor
• known drug allergy or hypersensitivity to a drug used in the study
• history of central brain injury
• patient treated with a psychotropic agent
• patient with a pacemaker
• severe renal insufficiency
• treatment by toremifene, flucloxacillin or fusidic acid in the preoperative or immediate postoperative period