Efficacy and Safety of Paliperidone ER in First Episode Psychosis

Efficacy and Safety of Paliperidone ER in Patients With First Episode Psychosis: an Open-label, Prospective Multi-center Study

The aim of the study is to investigate the efficacy and safety of Paliperidone ER in patients with first episode psychosis.

Inclusion Criteria:

• Aged 18-59 years and meet DSM-IV diagnostic criteria for first episode of schizophrenia, schizophreniform disorder, schizoaffective disorder or psychotic disorder NOS as assessed by using the Structured Clinical Interview for DSM-IV, research version.

Exclusion Criteria:

• Meeting DSM-IV criteria for another axis I diagnosis, including substance abuse or dependence
• Needing another nonantipsychotic psychotropic medication at enrollment
• Having a serious or unstable medical illness.
• Pregnant or lactating women or women without adequate contraception will be also excluded.