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| ID | Type | Description | Link |
|---|---|---|---|
| UMIN000003856 | Other Identifier | University hospital Medical Information Network |
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Patients with heart failure with preserved ejection fraction have a equally high risk for mortality and re-hospitalization as those with reduced ejection fraction. Effective management strategies are critically needed to be established for this type of heart failure. These patients have more hypertensive and ischemic etiology than those with reduced ejection fraction. The investigators hypothesis is that Ca channel blocker nifedipine can improve the heart failure clinical composite response endpoint compared with the conventional treatment in patients with heart failure with hypertension and/or coronary artery disease and preserved ejection fraction (>=50%) by echocardiography. This study is multi-center, prospective, randomized, open-label, and blinded-endpoint design.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Conventional therapy plus nifedipine | Experimental |
| |
| Conventional therapy | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Conventional therapy plus nifedipine | Drug | Participants will receive 10 to 60 mg of sustained-release nifedipine once a day until December 2014 |
|
| Measure | Description | Time Frame |
|---|---|---|
| Heart failure clinical composite response endpoint | up to 53 months |
| Measure | Description | Time Frame |
|---|---|---|
| Death | up to 53 months | |
| Cardiovascular death | up to 53 months | |
| Hospital admission |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hokkaido Univestity Hospital | Sapporo | 060-8638 | Japan |
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| ID | Term |
|---|---|
| D054144 | Heart Failure, Diastolic |
| ID | Term |
|---|---|
| D006333 | Heart Failure |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D009543 | Nifedipine |
| ID | Term |
|---|---|
| D004095 | Dihydropyridines |
| D011725 | Pyridines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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| Conventional therapy | Drug | Conventional therapy |
|
| up to 53 months |
| Hospital admission for cardiovascular disease | up to 53 months |
| Hospital admission for worsening heart failure | up to 53 months |
| Hospital admission for acute myocardial infarction, angina, coronary artery bypass grafting and percutaneous coronary intervention | up to 53 months |
| Stroke | up to 53 months |