Minimal Stimulation or Clomiphene Citrate in Treatment of Polycystic Ovary Syndrome

Minimal Stimulation or Clomiphene Citrate as First Line Therapy in Women With Polycystic Ovary Syndrome

The purpose of this study is to compare and determine the the efficacy of minimal stimulation and clomiphene citrate(CC) as the first-line treatment in infertile women with Polycystic Ovary Syndrome(PCOS).

All patients received 100 mg CC (Clomid®; Global Napi Pharmaceuticals, Cairo, Egypt) for 5 days starting from day 3 of spontaneous or induced menstruation. In group A (minimal stimulation), 2 vials of highly purified uFSH , 150 IU (Fostimon; IBSA, Lugano, Switzerland, 75 IU/vial) were given IM on cycle day 9. A total of 3 cycles was offered to each group.

Inclusion Criteria:

• PCOS
• No other infertility factors
• No previous use of ovarian stimulation drugs

Exclusion Criteria:

• Congenital adrenal hyperplasia
• Cushing syndrome
• Androgen secreting tumors