1/0.5 mg Estradiol/Norethindrone acetate Tablets test product dosed in either period.

1/0.5 mg Activella® Tablets reference product dosed in either period.

Bioequivalence is established if the 90% confidence interval for the ln-transformed geometric mean between the reference (R) and test (T) product fall within the interval of 80-125%.

ANOVA is to be used to identify the source contributions by factors including subjects, period, formulation and potential interactions. The geometric mean ratio together with the ANOVA residual mean error term are used to identify the statistical basis for the 90% confidence interval for the ratio of the population means (Test [T]/Reference[R]) of the identified metrics (e.g. AUC, Cmax).

1/0.5 mg Estradiol/Norethindrone acetate Tablets test product dosed in either period.

1/0.5 mg Activella® Tablets reference product dosed in either period.

Bioequivalence is established if the 90% confidence interval for the ln-transformed geometric mean between the reference (R) and test (T) product fall within the interval of 80-125%.

ANOVA is to be used to identify the source contributions by factors including subjects, period, formulation and potential interactions. The geometric mean ratio together with the ANOVA residual mean error term are used to identify the statistical basis for the 90% confidence interval for the ratio of the population means (Test [T]/Reference[R]) of the identified metrics (e.g. AUC, Cmax).

1/0.5 mg Estradiol/Norethindrone acetate Tablets test product dosed in either period.

1/0.5 mg Activella® Tablets reference product dosed in either period.

Bioequivalence is established if the 90% confidence interval for the ln-transformed geometric mean between the reference (R) and test (T) product fall within the interval of 80-125%.

ANOVA is to be used to identify the source contributions by factors including subjects, period, formulation and potential interactions. The geometric mean ratio together with the ANOVA residual mean error term are used to identify the statistical basis for the 90% confidence interval for the ratio of the population means (Test [T]/Reference[R]) of the identified metrics (e.g. AUC, Cmax).

1/0.5 mg Estradiol/Norethindrone acetate Tablets test product dosed in either period.

1/0.5 mg Activella® Tablets reference product dosed in either period.

Bioequivalence is established if the 90% confidence interval for the ln-transformed geometric mean between the reference (R) and test (T) product fall within the interval of 80-125%.

ANOVA is to be used to identify the source contributions by factors including subjects, period, formulation and potential interactions. The geometric mean ratio together with the ANOVA residual mean error term are used to identify the statistical basis for the 90% confidence interval for the ratio of the population means (Test [T]/Reference[R]) of the identified metrics (e.g. AUC, Cmax).

1/0.5 mg Estradiol/Norethindrone acetate Tablets test product dosed in either period.

1/0.5 mg Activella® Tablets reference product dosed in either period.

Bioequivalence is established if the 90% confidence interval for the ln-transformed geometric mean between the reference (R) and test (T) product fall within the interval of 80-125%.

ANOVA is to be used to identify the source contributions by factors including subjects, period, formulation and potential interactions. The geometric mean ratio together with the ANOVA residual mean error term are used to identify the statistical basis for the 90% confidence interval for the ratio of the population means (Test [T]/Reference[R]) of the identified metrics (e.g. AUC, Cmax).

1/0.5 mg Estradiol/Norethindrone acetate Tablets test product dosed in either period.

1/0.5 mg Activella® Tablets reference product dosed in either period.

This analysis was for informational purposes only and was not used to establish bioequivalence.

ANOVA is to be used to identify the source contributions by factors including subjects, period, formulation and potential interactions. The geometric mean ratio together with the ANOVA residual mean error term are used to identify the statistical basis for the 90% confidence interval for the ratio of the population means (Test [T]/Reference[R]) of the identified metrics (e.g. AUC, Cmax).

1/0.5 mg Estradiol/Norethindrone acetate Tablets test product dosed in either period.

1/0.5 mg Activella® Tablets reference product dosed in either period.

This analysis was for informational purposes only and was not used to establish bioequivalence.

ANOVA is to be used to identify the source contributions by factors including subjects, period, formulation and potential interactions. The geometric mean ratio together with the ANOVA residual mean error term are used to identify the statistical basis for the 90% confidence interval for the ratio of the population means (Test [T]/Reference[R]) of the identified metrics (e.g. AUC, Cmax).

1/0.5 mg Estradiol/Norethindrone acetate Tablets test product dosed in either period.

1/0.5 mg Activella® Tablets reference product dosed in either period.

This analysis was for informational purposes only and was not used to establish bioequivalence.

ANOVA is to be used to identify the source contributions by factors including subjects, period, formulation and potential interactions. The geometric mean ratio together with the ANOVA residual mean error term are used to identify the statistical basis for the 90% confidence interval for the ratio of the population means (Test [T]/Reference[R]) of the identified metrics (e.g. AUC, Cmax).

1/0.5 mg Estradiol/Norethindrone acetate Tablets test product dosed in either period.

1/0.5 mg Activella® Tablets reference product dosed in either period.

This analysis was for informational purposes only and was not used to establish bioequivalence.

ANOVA is to be used to identify the source contributions by factors including subjects, period, formulation and potential interactions. The geometric mean ratio together with the ANOVA residual mean error term are used to identify the statistical basis for the 90% confidence interval for the ratio of the population means (Test [T]/Reference[R]) of the identified metrics (e.g. AUC, Cmax).

1/0.5 mg Estradiol/Norethindrone acetate Tablets test product dosed in either period.

1/0.5 mg Activella® Tablets reference product dosed in either period.

This analysis was for informational purposes only and was not used to establish bioequivalence.

ANOVA is to be used to identify the source contributions by factors including subjects, period, formulation and potential interactions. The geometric mean ratio together with the ANOVA residual mean error term are used to identify the statistical basis for the 90% confidence interval for the ratio of the population means (Test [T]/Reference[R]) of the identified metrics (e.g. AUC, Cmax).

1/0.5 mg Estradiol/Norethindrone acetate Tablets test product dosed in either period.

1/0.5 mg Activella® Tablets reference product dosed in either period.

This analysis was for informational purposes only and was not used to establish bioequivalence.

ANOVA is to be used to identify the source contributions by factors including subjects, period, formulation and potential interactions. The geometric mean ratio together with the ANOVA residual mean error term are used to identify the statistical basis for the 90% confidence interval for the ratio of the population means (Test [T]/Reference[R]) of the identified metrics (e.g. AUC, Cmax).

1/0.5 mg Estradiol/Norethindrone acetate Tablets test product dosed in either period.

1/0.5 mg Activella® Tablets reference product dosed in either period.

This analysis was for informational purposes only and was not used to establish bioequivalence.

ANOVA is to be used to identify the source contributions by factors including subjects, period, formulation and potential interactions. The geometric mean ratio together with the ANOVA residual mean error term are used to identify the statistical basis for the 90% confidence interval for the ratio of the population means (Test [T]/Reference[R]) of the identified metrics (e.g. AUC, Cmax).

1/0.5 mg Estradiol/Norethindrone acetate Tablets test product dosed in either period.

1/0.5 mg Activella® Tablets reference product dosed in either period.

This analysis was for informational purposes only and was not used to establish bioequivalence.

ANOVA is to be used to identify the source contributions by factors including subjects, period, formulation and potential interactions. The geometric mean ratio together with the ANOVA residual mean error term are used to identify the statistical basis for the 90% confidence interval for the ratio of the population means (Test [T]/Reference[R]) of the identified metrics (e.g. AUC, Cmax).

1/0.5 mg Estradiol/Norethindrone acetate Tablets test product dosed in either period.

1/0.5 mg Activella® Tablets reference product dosed in either period.

This analysis was for informational purposes only and was not used to establish bioequivalence.

ANOVA is to be used to identify the source contributions by factors including subjects, period, formulation and potential interactions. The geometric mean ratio together with the ANOVA residual mean error term are used to identify the statistical basis for the 90% confidence interval for the ratio of the population means (Test [T]/Reference[R]) of the identified metrics (e.g. AUC, Cmax).

1/0.5 mg Estradiol/Norethindrone acetate Tablets test product dosed in either period.

1/0.5 mg Activella® Tablets reference product dosed in either period.

This analysis was for informational purposes only and was not used to establish bioequivalence.

ANOVA is to be used to identify the source contributions by factors including subjects, period, formulation and potential interactions. The geometric mean ratio together with the ANOVA residual mean error term are used to identify the statistical basis for the 90% confidence interval for the ratio of the population means (Test [T]/Reference[R]) of the identified metrics (e.g. AUC, Cmax).

1/0.5 mg Estradiol/Norethindrone acetate Tablets test product dosed in either period.

1/0.5 mg Activella® Tablets reference product dosed in either period.

This analysis was for informational purposes only and was not used to establish bioequivalence.

ANOVA is to be used to identify the source contributions by factors including subjects, period, formulation and potential interactions. The geometric mean ratio together with the ANOVA residual mean error term are used to identify the statistical basis for the 90% confidence interval for the ratio of the population means (Test [T]/Reference[R]) of the identified metrics (e.g. AUC, Cmax).

1/0.5 mg Estradiol/Norethindrone acetate Tablets test product dosed in either period.

1/0.5 mg Activella® Tablets reference product dosed in either period.

This analysis was for informational purposes only and was not used to establish bioequivalence.

ANOVA is to be used to identify the source contributions by factors including subjects, period, formulation and potential interactions. The geometric mean ratio together with the ANOVA residual mean error term are used to identify the statistical basis for the 90% confidence interval for the ratio of the population means (Test [T]/Reference[R]) of the identified metrics (e.g. AUC, Cmax).

1/0.5 mg Estradiol/Norethindrone acetate Tablets test product dosed in either period.

1/0.5 mg Activella® Tablets reference product dosed in either period.

This analysis was for informational purposes only and was not used to establish bioequivalence.

ANOVA is to be used to identify the source contributions by factors including subjects, period, formulation and potential interactions. The geometric mean ratio together with the ANOVA residual mean error term are used to identify the statistical basis for the 90% confidence interval for the ratio of the population means (Test [T]/Reference[R]) of the identified metrics (e.g. AUC, Cmax).

1/0.5 mg Estradiol/Norethindrone acetate Tablets test product dosed in either period.

1/0.5 mg Activella® Tablets reference product dosed in either period.

This analysis was for informational purposes only and was not used to establish bioequivalence.

ANOVA is to be used to identify the source contributions by factors including subjects, period, formulation and potential interactions. The geometric mean ratio together with the ANOVA residual mean error term are used to identify the statistical basis for the 90% confidence interval for the ratio of the population means (Test [T]/Reference[R]) of the identified metrics (e.g. AUC, Cmax).

1/0.5 mg Estradiol/Norethindrone acetate Tablets test product dosed in either period.

1/0.5 mg Activella® Tablets reference product dosed in either period.

This analysis was for informational purposes only and was not used to establish bioequivalence.

ANOVA is to be used to identify the source contributions by factors including subjects, period, formulation and potential interactions. The geometric mean ratio together with the ANOVA residual mean error term are used to identify the statistical basis for the 90% confidence interval for the ratio of the population means (Test [T]/Reference[R]) of the identified metrics (e.g. AUC, Cmax).