Contribution of Salivary Cortisol in the Detection of Infra-clinic Cortisol Adenoma (ACIC)

Detection of Infra-clinic Cortisol Adenoma (ACIC) in a Population of Android Obese With High Metabolic Risk: Contribution of Salivary Cortisol at 23 Hours

The main objective of the study is to assess the sensitivity of the salivary cortisol dosage at 23 hours compared to the serum cortisol dosage at 8 am after overnight 1-mg dexamethasone suppression test (Suppression of serum cortisol <1.8 μg/dL ) as the reference method for the detection of ACIC in obese subjects

Inclusion Criteria:

• Adult patients (≥18 years)
• Signed informed consent
• Subjects affiliated with an appropriate social security system
• Body mass index above 30 kg/m2 and
• Pathological waist circumference according to criteria of NCEP ATPIII (men : 94 cm and women : 80 cm)

Exclusion Criteria:

• Pregnancy
• Sepsis
• Recent surgery (less than 30 days)
• Any recent severe acute conditions requiring hospitalisation (less than 30 days)
• Recent use (< 7 days) of oral steroids, inhaled, dermal, collyrium, infiltration
• Long-term oral corticosteroids
• Nicotinic substitute or per os licorice in 2 weeks before the inclusion