Number of patients with a serum cortisol > 18 ng/ml reached

The main objective of the study is to assess the sensitivity of the salivary cortisol dosage at 23 hours compared to the serum cortisol dosage at 8 am after overnight 1-mg dexamethasone suppression test (Suppression of serum cortisol <1.8 μg/dL ) as the reference method for the detection of ACIC in obese subjects

Inclusion Criteria:

• Adult patients (≥18 years)
• Signed informed consent
• Subjects affiliated with an appropriate social security system
• Body mass index above 30 kg/m2 and
• Pathological waist circumference according to criteria of NCEP ATPIII (men : 94 cm and women : 80 cm)

Exclusion Criteria:

• Pregnancy
• Sepsis
• Recent surgery (less than 30 days)
• Any recent severe acute conditions requiring hospitalisation (less than 30 days)
• Recent use (< 7 days) of oral steroids, inhaled, dermal, collyrium, infiltration
• Long-term oral corticosteroids
• Nicotinic substitute or per os licorice in 2 weeks before the inclusion