Carvedilol Post-intervention Long-term Administration in Large-scale Trial

Carvedilol Post-intervention Long-term Administration in Large-scale Randomized Controlled Trial

The purpose of this study is to evaluate whether beta-blocker therapy improves 6-year clinical outcomes in patients with ST-segment elevation acute myocardial infarction and preserved left ventricular ejection fraction after primary percutaneous coronary intervention.

Beta-blocker therapy is recommended after ST-segment elevation acute myocardial infarction (STEMI) in the current guidelines although its efficacy in those patients who have undergone primary percutaneous coronary intervention (PCI) has not been adequately evaluated. The purpose of this study is to evaluate whether beta-blocker, carvedilol improves 6-year clinical outcomes in patients with STEMI and preserved left ventricular ejection fraction after primary PCI. The design of this study is multicenter, open-label, randomized controlled trial enrolling 1300 patients without any exclusion criteria.

Inclusion Criteria:

• Patients with STEMI after primary PCI
• Patients with left ventricular ejection fraction more than or equal to 40%

Exclusion Criteria:

• Patients with left ventricular ejection fraction less than 40%
• Patients with contraindication for beta-blocker
• Patients with implantable cardioverter defibrillators
• Patients with end-stage malignancy