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The purpose of this study is to determine whether 14 days nutritional supplementation with Ready to use therapeutic Food (RUTF) or micronutrients alone to children having an infection will prevent malnutrition and reduce the frequency of morbidity.
Anorexia due to infection might lead to weight loss. In many settings total recovery is problematic what might result in a permanent lower weight. A short period high quality food supplementation could improve weight gain after an infection.
A complete high quality food will be tested, but also micronutrients alone as there is no information on what children with an infection exactly need as a supplement.
Children aged 6-59 months presenting with diarrhoea, malaria or lower respiratory tract infection (LRTI) are provided for 2 weeks with
The followup period is 6 months. Anthropometric indicators and morbidity are assessed monthly. Participants are invited to attend the study clinic if any signs of disease are noticed.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Ready to Use Therapeutic Food (RUTF) | Experimental | 500 kcal /day for 2 weeks |
|
| Micronutrient Powder (MNP) | Experimental | 2 x 1 g sachets micronutrients /day for 2 weeks |
|
| no supplement | No Intervention | no supplementation |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ready to Use Therapeutic Food (RUTF) | Dietary Supplement | 1 sachet/day, 500 kcal and multi micronutrients (fortified high quality food(RUTF),for 2 weeks after an illness (malaria, diarrhoea, pneumonia) |
| Measure | Description | Time Frame |
|---|---|---|
| "negative nutritional outcome" of a child | The incidence of a negative nutritional outcome will be defined in two different ways according to the baseline nutritional status. i) for children with no malnourishment at time of entry into study, "negative nutritional outcome" is defined as progression to moderate or severe malnourishment ii) for children with moderate malnourishment at time of entry into study, "negative nutritional outcome" is defined as loss of ³10% of baseline weight or progression to severe malnourishment, whichever is reached first. | 6 months follow-up |
| Measure | Description | Time Frame |
|---|---|---|
| Number of new events of a study disease | study disease: malaria, diarrhoea, and LRTI | 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Saskia Kam van der, Ir | Medecins Sans Frontieres Amsterdam | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Goronyo health clinic outpatient department | Goronyo | Sokoto State | Nigeria |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26859559 | Derived | van der Kam S, Salse-Ubach N, Roll S, Swarthout T, Gayton-Toyoshima S, Jiya NM, Matsumoto A, Shanks L. Effect of Short-Term Supplementation with Ready-to-Use Therapeutic Food or Micronutrients for Children after Illness for Prevention of Malnutrition: A Randomised Controlled Trial in Nigeria. PLoS Med. 2016 Feb 9;13(2):e1001952. doi: 10.1371/journal.pmed.1001952. eCollection 2016 Feb. |
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|
| Micronutrient Powder (MNP) | Dietary Supplement | 2 sachets / day for 14 days after an illness (diarrheoea, malaria, pneumonia) |
|
|
| ID | Term |
|---|---|
| D044342 | Malnutrition |
| D008288 | Malaria |
| D003967 | Diarrhea |
| D003289 | Convalescence |
| D001835 | Body Weight |
| ID | Term |
|---|---|
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D011528 | Protozoan Infections |
| D010272 | Parasitic Diseases |
| D007239 | Infections |
| D000096724 | Mosquito-Borne Diseases |
| D000079426 | Vector Borne Diseases |
| D012817 | Signs and Symptoms, Digestive |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
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