Study to Investigate the Pharmacodynamic Effect of a Single Dose of AZD2516 in Healthy Male Subjects

A Double-blind, Randomized, Placebo-controlled, Two-centre, Phase IIa Pharmacodynamic Cross-over Study to Assess the Effect of AZD2516 on the Total Number of Reflux Episodes in Healthy Male Volunteers

The purpose of this study is to investigate the pharmacodynamic effect of AZD2516 in healthy male subjects.

A double-blind, randomized, placebo-controlled, two-centre, phase IIa pharmacodynamic cross-over study to assess the effect of AZD2516 on the total number of reflux episodes in healthy male volunteers.

Inclusion Criteria:

• Provision of signed informed consent
• Healthy male subjects
• Age 18-45 years, inclusive

Exclusion Criteria:

• Clinically significant illness within the 2 weeks prior to the first dose of study drug
• History of clinically significant cardiovascular, respiratory, renal, hepatic, neurological, mental or gastrointestinal disease
• Need for concomitant medications during the study