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This study is planned to medicate oral T3(Liothyronine)to the patients who are planned to have OPCAB(off- pump coronary bypass graft surgery. The aim of this study was to assess the effects of oral triiodothyronine (T3) therapy on postoperative thyroid hormone concentrations, hemodynamic variables and outcomes in patients undergoing OPCAB in a randomized, controlled trial.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| T3 | Experimental | triiodothyronine |
|
| cyanocobalamin | Active Comparator | vitamin B12 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| liothyronine sodium | Drug | liothyronine sodium 20ug, every 12hour (before anesthetic induction, total 4 times) |
|
| Measure | Description | Time Frame |
|---|---|---|
| compare the serum T3 concentrations and the number of patients with serum T3 concentrations below the normal range between the groups | until 36 hours after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| difference of hemodynamic performance and myocardial injury | difference of hemodynamic performance and myocardial injury between the groups | during surgery and 36 hr after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| major morbidity endpoints including acute renal failure, cardiovascular failure, stroke, mediastinitis, need for ventilator support for >48 h, and new onset atrial fibrillation | until discharge of hospital |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Yong-Sun Choi, MD, Ph.D | Anesthesiology & Pain Medicine, Severance Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Severance Hospital | Seoul | South Korea |
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| placebo | Drug | vitamin B12 |
|
| ID | Term |
|---|---|
| D005067 | Euthyroid Sick Syndromes |
| ID | Term |
|---|---|
| D013959 | Thyroid Diseases |
| D004700 | Endocrine System Diseases |
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| ID | Term |
|---|---|
| D014284 | Triiodothyronine |
| ID | Term |
|---|---|
| D013970 | Thyronines |
| D013963 | Thyroid Hormones |
| D006728 | Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |
| D013974 | Thyroxine |
| D024322 | Amino Acids, Aromatic |
| D000598 | Amino Acids, Cyclic |
| D000596 | Amino Acids |
| D000602 | Amino Acids, Peptides, and Proteins |
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