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| Name | Class |
|---|---|
| Seoul National University Hospital | OTHER |
| Gachon University Gil Medical Center | OTHER |
| Inha University Hospital | OTHER |
| Inje University |
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To assess the immunogenicity and safety of the vero cell-derived inactivated JE vaccine in Korean healthy children aged 12~23 months
To compare the Vero cell-derived inactivated Japanese encephalitis(JE) vaccine 'KD-287(JEIMMUGEN INJ.)' with the mouse brain-derived inactivated JE vaccine in terms of the immunogenicity and safety, in Korean healthy children aged 12~23 months
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| vero cell-derived JE vaccine | Experimental | vero cell-derived vaccine group |
|
| Mouse brain-derived JE vaccine | Active Comparator | Mouse brain-derived JE vaccine group |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| JE vaccine | Biological | 3 times, IM |
|
| Measure | Description | Time Frame |
|---|---|---|
| immunogenicity | the seroconversion rates for JE antibodies 4 weeks after 3rd vaccination | pre-dose, after 3rd vaccination |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Hoan Jong Lee, PhD | Seoul National University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Hospital | Seoul | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25567119 | Derived | Yun KW, Lee HJ, Kang JH, Eun BW, Kim YJ, Kim KH, Kim NH, Hong YJ, Kim DH, Kim HM, Cha SH. Safety and immunogenicity of a freeze-dried, Vero cell culture-derived, inactivated Japanese encephalitis vaccine (KD-287, ENCEVAC(R)) versus a mouse brain-derived inactivated Japanese encephalitis vaccine in children: a phase III, multicenter, double-blinded, randomized trial. BMC Infect Dis. 2015 Jan 8;15:7. doi: 10.1186/s12879-014-0744-4. |
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| ID | Term |
|---|---|
| D004672 | Encephalitis, Japanese |
| ID | Term |
|---|---|
| D004671 | Encephalitis, Arbovirus |
| D018792 | Encephalitis, Viral |
| D020805 | Central Nervous System Viral Diseases |
| D002494 | Central Nervous System Infections |
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| ID | Term |
|---|---|
| C000607270 | SA-14-14-2 vaccine |
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| OTHER |
| Korea Cancer Center Hospital | OTHER |
| Samsung Medical Center | OTHER |
| The Catholic University of Korea | OTHER |
| Ewha Womans University | OTHER |
| Wonju Severance Christian Hospital | OTHER |
| Kyunghee University Medical Center | OTHER |
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| D007239 | Infections |
| D000069544 | Infectious Encephalitis |
| D001102 | Arbovirus Infections |
| D000079426 | Vector Borne Diseases |
| D000096724 | Mosquito-Borne Diseases |
| D014777 | Virus Diseases |
| D012327 | RNA Virus Infections |
| D018177 | Flavivirus Infections |
| D018178 | Flaviviridae Infections |
| D004660 | Encephalitis |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D000090862 | Neuroinflammatory Diseases |