QUALYOR is a prospective study on the predictive value for fragility fracture of various new techniques assessing bone quality, among postmenopausal women with low bone mass.

Inclusion Criteria:

• 50 or older women
• post-menopausal since at least one year
• with osteopenia (T-score between -1.0 and -2.5 (with clinical factor risk) or -3.0 (without clinical factor risk)

Exclusion Criteria:

• corticosteroid therapy > 3 months, at least 7.5mg/day equivalent prednisolon (stopped since at least 1 year)
• osteoporosis treatment antecedent
• fragility fracture antecedent
• on going post-menopausal hormonal treatment
• clinical signs of hepatic, cardiac or respiratory insufficiency, diseases possibly affecting bone metabolism
• life expectancy < 4 years, mental or serious illness

50 years old or older women with lowered Bone Mineral Density