The purpose of this study is to determine safety and feasibility of Chemo-Immunotherapy using cyclophosphamide, docetaxel, OK-432, and autologous immature dendritic cells for patients with relapsed and refractory head and neck squamous cell carcinoma.

Inclusion Criteria:

1. The patients with relapsed and refractory head and neck squamous cell carcinoma

2. 20 years and older

3. ECOG performance status 0-1

4. More than 4 weeks must have elapsed from the time of radiation therapy and the last dose of chemotherapy

5. Tumor lesions are accessible to intratumoral dendritic cells injection

6. Patients who are able to do oral ingestion

7. Patients must have normal organ and marrow functions as follows:

   • Hb>9.0 mg/dl
   • Ht>25%
   • WBC>4000/mm3
   • Platelet count>100,000/mm3
   • T-Bil<1.5mg/dl
   • GOT\