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The ideal mean arterial pressure in patients with septic shock is unknown. The expert's recommandations have stated a target between 65 and 70 mm Hg. However the scientific basis are weak. Indead there are only few prospective studies which addressed this question without clear answer. Therefore we designed a RCT in order to assess the effect on mortality of two levels of mean arterial pressure in patients with septic shock.(800 patients, 30 centres)
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| high pressure | Active Comparator |
| |
| normal pressure | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| maintain mean arterial pressure between 80-85 mm Hg | Drug | protocolized hemodynamic care aiming to maintain mean arterial pressure between 80-85 mm Hg |
|
| Measure | Description | Time Frame |
|---|---|---|
| mortality | day 28 |
| Measure | Description | Time Frame |
|---|---|---|
| decrease in mortality at day 90 | day 90 | |
| decrease in sequential organ failure assessment | day 1 to day 28 | |
| extra renal replacement free days |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University hospital Angers | Angers | 49933 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40960603 | Derived | Pirracchio R, Fong N, Legrand M. Heterogeneity in the response to a high vs low mean arterial pressure target in patients with septic shock a post hoc analysis of a randomized controlled trial. Intensive Care Med. 2025 Oct;51(10):1775-1783. doi: 10.1007/s00134-025-08104-8. Epub 2025 Sep 17. | |
| 24635770 | Derived |
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| maintain mean arterial pressure between 65-70 mm Hg | Other | protocolized hemodynamic care aiming to maintain mean arterial pressure between 65-70 mm Hg |
|
| day 28 |
| renal function | day 1 to day 28 |
| amount of fluids | day 1 to end of shock |
| catecholamines free days | day 1 to day 28 |
| Asfar P, Meziani F, Hamel JF, Grelon F, Megarbane B, Anguel N, Mira JP, Dequin PF, Gergaud S, Weiss N, Legay F, Le Tulzo Y, Conrad M, Robert R, Gonzalez F, Guitton C, Tamion F, Tonnelier JM, Guezennec P, Van Der Linden T, Vieillard-Baron A, Mariotte E, Pradel G, Lesieur O, Ricard JD, Herve F, du Cheyron D, Guerin C, Mercat A, Teboul JL, Radermacher P; SEPSISPAM Investigators. High versus low blood-pressure target in patients with septic shock. N Engl J Med. 2014 Apr 24;370(17):1583-93. doi: 10.1056/NEJMoa1312173. Epub 2014 Mar 18. |
| ID | Term |
|---|---|
| D012772 | Shock, Septic |
| ID | Term |
|---|---|
| D018805 | Sepsis |
| D007239 | Infections |
| D018746 | Systemic Inflammatory Response Syndrome |
| D007249 | Inflammation |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012769 | Shock |
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