Interferon Alpha Lozenges Plus Oseltamivir for Influenza Treatment

Pilot Study of Interferon Alpha Lozenges Plus Oseltamivir in the Treatment of Influenza A Infection

This study aims to evaluate the safety and effect of interferon-alpha lozenges when used in combination with oseltamivir (Tamiflu) to treat influenza.

Inclusion Criteria:

• fever >=38C
• one or more respiratory symptoms (e.g. cough, rhinorrhea or sore throat) plus one or more constitutional symptoms (e.g. chills, headache, malaise and myalgias)of < 48 hours' duration
• body weight > 40 kg
• positive for influenza A (nasal swab rapid test)

Exclusion Criteria:

• pregnancy/lactation
• history of depression or psychiatric disorders
• history of conditions that could complicate flu infection, such as chronic pulmonary, cardiac, renal, or metabolic disorders
• use of immunosuppressive therapy
• HIV infection