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Patients from group A, during maintenance of anesthesia, at the time of trocar insertion, will listen (via MP3) a piece of one of two stories, "Puss in Boots" and "Pinocchio", each followed by four keywords. In group B, patients will be isolated from the sounds of the operating room using specific headphones.
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| Measure | Description | Time Frame |
|---|---|---|
| Hormones levels | The blood sample will be taken during anaesthesia to determine intraoperative hormones (cortisol + prolactine) levels. | 5 minutes after achieving a pneumoperitoneum pressure of 12 mmHg |
| Hormones levels | The blood sample will be taken 30 minutes before induction of anaesthesia to determine baseline hormones (cortisol + prolactine) levels. | Baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Remifentanil concentration | One blood sample will be taken to determine steady state concentration of remifentanil (only in a subset of patients). | 5 minutes after achieving a pneumoperitoneum pressure of 12 mmHg |
| Memory |
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Inclusion Criteria:
Exclusion Criteria:
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Patients sheduled for minor elective laparoscopic surgery
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Catholic University of Sacred Heart | Recruiting | Rome | Italy |
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Whole blood and serum.
Patients will be asked to associate with keywords the first thing that comes them to mind (implicit memory). Also eplicit memory and dreams recall will be tested at the same time. The content of intraoperative dreams (confirmed by a brief post-anesthesia interview) will be analyzed using the 5-point Likert scale.
| Approximately 24 hours after surgery for explicit memory, implicit memory and for dreams recall detected after awakening from anesthesia |
| Primary auditory cortex activation | ERP-EEG monitoring system with 128 channel EGI GES300 | 5 minutes after achieving a pneumoperitoneum pressure of 12 mmHg |