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Pain that persists after the healing of a surgical wound has previously been described as an important, but often unrecognized clinical problem. Persistent postsurgical (chronic postoperative pain) is the consequence of either ongoing inflammation or more common neuropathic pain as a result of surgical damage to peripheral nerves.
Previous studies have shown that chronic pain is a frequent and serious complication following thoracic surgery. However, the prevalence of chronic pain following both thoracoscopy and anterior thoracotomy in patients with pulmonary malignancies is poorly characterized and the impact of this pain on patients' lives remains unclear. Thus, this study aims to investigate the prevalence of chronic pain following thoracoscopy or anterior thoracotomy, and the severity and impact of persistent post-surgical pain on daily life.
This study is working with several hypotheses: 1.) persistent postsurgical pain following lung cancer surgery is predominantly of neuropathic nature and the presence of neuropathic symptoms increases the severity of postsurgical pain and reduces the patient's quality of life, 2.) the prevalence of chronic pain is reduced over time, and 3.) less invasive thoracic surgical interventions reduces the risk of the development of chronic pain.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Thoracic surgical patients | Patients with pulmonary malignancies |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Thoracic surgery | Procedure | Thoracoscopy or anterior thoracotomy |
|
| Measure | Description | Time Frame |
|---|---|---|
| Presence of persistent postsurgical pain | Within 10 years after thoracic surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Location of persistent postsurgical pain | Within 10 years after thoracic surgery | |
| Duration of postsurgical pain | Within 10 years after thoracic surgery | |
| Course of persistent postsurgical pain |
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Inclusion Criteria:
Exclusion Criteria:
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Patients who underwent thoracic surgery due to pulmonary malignancies at the Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Skejby, Denmark
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| Name | Affiliation | Role |
|---|---|---|
| Kasper Grosen, PhDS, MHScS, RN | Department of Cardiothoracic and Vascular surgery, Aarhus University Hospital, Skejby, Denmark | Principal Investigator |
| Hans K Pilegaard, MD | Department of Cardiothoracic and Vascular surgery, Aarhus University Hospital, Skejby, Denmark | Study Director |
| Vibeke Hjortdal, MD, Professor, DMSc, PhD | Department of Cardiothoracic and Vascular surgery, Aarhus University Hospital, Skejby, Denmark | Study Chair |
| Mogens P Jensen, MD, PhD | Department of Rheumatology, Aarhus University Hospital, Aarhus Hospital, Denmark | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Cardiothoracic and Vascular surgery, Aarhus University Hospital, Skejby | Aarhus N | DK-8200 | Denmark |
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| ID | Term |
|---|---|
| D010149 | Pain, Postoperative |
| D008175 | Lung Neoplasms |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010146 | Pain |
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| ID | Term |
|---|---|
| D019616 | Thoracic Surgical Procedures |
| ID | Term |
|---|---|
| D013514 | Surgical Procedures, Operative |
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| Within 10 years after thoracic surgery |
| Severity of postsurgical pain | Within 10 years after thoracic surgery |
| Characteristics of persistent postsurgical pain | Within 10 years after thoracic surgery |
| Symptoms associated with persistent postsurgical pain | Within 10 years after thoracic surgery |
| Treatment of and effect of treatment on persistent postsurgical pain | Within 10 years after thoracic surgery |
| Effect of postsurgical pain on activity, mood, walking ability, work, interpersonal relations, sleep and quality of life | Within 10 years after thoracic surgery |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D012142 | Respiratory Tract Neoplasms |
| D013899 | Thoracic Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |