Leukocyte Dysfunction in Diabetic Patients.

Leukocyte Dysfunction in Diabetic Patients.

The purpose of this study is to study impairment of white blood cell function in patients with type II diabetes.

Leucocytes from poorly controlled diabetes exhibit aberrant chemotaxis, increased susceptibility to bacterial infection, leukotriene production, lysosomal enzyme release, proinflammatory cytokine expression and production of reactive oxygen species. Aberrant glucose concentration in diabetics affects functions of peripheral blood system as well as the immune system leading to impaired host defense. Impaired wound healing is a serious complication associated with diabetes. We hypothesized that impairment in leukocyte function results in dysfunctional inflammatory response in diabetic wounds. The proposed studies focus on characterizing mechanisms that will improve our understanding of the dysfunctional inflammatory response resulting in non-healing chronic wounds in diabetics.

Inclusion Criteria:

• Adults ages 40-60 yrs old clinically diagnosed with Type II Diabetes
• Adults ages 40-60 yrs old without Diabetes

Exclusion Criteria:

• Unable to provide informed consent
• Pregnant Females
• Therapeutically Immuno-compromised