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| ID | Type | Description | Link |
|---|---|---|---|
| 0909M72358 | Other Identifier | IRB, University of Minnesota | |
| 1K07CA128952-01A2 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Cancer Institute (NCI) | NIH |
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Certain plant foods are high in furanocoumarins. Test tube and animal studies suggest that furanocoumarins may help prevent cancer. It is difficult to determine in humans if furanocoumarins do prevent cancer because there isn't an objective way to tell who has eaten these compounds. This study will develop a urine test to determine if an individual ate foods that contain furanocoumarins.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Furanocoumarin | Experimental | Includes participants first refraining from eating foods with furanocoumarins for one week, followed by 2 weeks of increasing furanocoumarin consumption. Participants will be asked to consume cooked parsnips and parsley. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cooked parsnips with parsley | Dietary Supplement | Beginning on Day 9 participants will be given cooked parsnips with parsley at a dose of 2 grams total apiaceous vegetable/kilogram body weight for period 1, and 4 gram/kilogram body weight for period 2. |
| Measure | Description | Time Frame |
|---|---|---|
| Urinary Biomarker Results for Dietary Furanocoumarins | determine the optimal conditions for furanocoumarin identification and quantification in human urine | Week 1 |
| Measure | Description | Time Frame |
|---|---|---|
| Mean Concentration of Dietary Furanocoumarin in Urine | Determine dose response of dietary furanocoumarin in urine - Comparison of Pre-Dose, Low-Dose and High Dose diet of furanocoumarin in subjects' urine collected (ng/ml). | Week 1, 2 and 3 |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Sabrina Peterson, Ph.D. | University of Minnesota | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Food Science and Nutrition, University of Minnesota | Saint Paul | Minnesota | 55108 | United States |
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| ID | Term |
|---|---|
| D009369 | Neoplasms |
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