Cardiorenal Interactions During Treatment of Acute Decompensated Heart Failure: Diuretics Versus Ultrafiltration

Cardiorenal Interactions During Treatment of Acute Decompensated Heart Failure: Diuretics Versus Ultrafiltration

The CRUF trial is a prospective randomized monocentric trial comparing different impact of diuretics versus ultrafiltration on renal congestion, plasma refill rate, echocardiographic filling pressures, neurohormonal activation and biomarkers of Acute Kidney Injury (AKI).

Inclusion Criteria:

• >18 years old

• Severe systolic heart failure with ejection fraction <40%

• And Hospitalisation for decompensated heart failure

• And New York Heart Association (NYHA) III or IV

• And 1 of the following:

  • Jugular vein distension>6cm
  • Tissue Doppler mitral annulus lateral>12 or medial>15
  • Chest X-ray: pulmonary edema or pleural effusion

Exclusion Criteria:

• Need for inotropic or vasopressive agents
• Use of intravenous (IV) contrast media
• Acute coronary syndrome
• Need of dialysis
• Severe co-morbidity
• Contra-indications for anticoagulation
• Pregnancy