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| Name | Class |
|---|---|
| Aalborg Psychiatric Hospital | OTHER |
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Clozapine remain the drug of choice for treatment resistant schizophrenia and up to 60% of patients not responding to other antipsychotics will respond to clozapine. However, the use of clozapine is restricted due to the risk of agranulocytosis and consequently the need for mandatory hematological monitoring. CHEMPAQ XBC is a point-of-care device that can be used in patients home and analyze WBC and granulocytes by a single capillary blood drop. This study aims to investigate whether this new procedure increases the acceptability of clozapine
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CHEMPAQ-venous-CHEMPAQ-venous | The two arms only differ in order of kind of blood samples. |
| |
| Venous-CHEMPAQ-Venous-CHEMPAQ | The two arms only differ in order of kind of blood samples. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Venous blod sample | Device | Regular venous blood sample withdrawn from the laboratory |
|
| Measure | Description | Time Frame |
|---|---|---|
| Pain sensation | Pain sensation was measured using a visual analog scale (VAS) | Monthly for four months |
| Measure | Description | Time Frame |
|---|---|---|
| The benefits of CHEMPAQ | Caregivers and patients were asked about the benefits of using CHEMPAQ for hematological clozapine monitoring. | Monthly for four months |
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Inclusion Criteria:
Exclusion Criteria:
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Patients treated with clozapine
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| Name | Affiliation | Role |
|---|---|---|
| Jimmi Nielsen, MD | Aalborg Psychiatric Hospital, Aarhus University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Psychiatric Center Roskilde | Greve | Greve | 2670 | Denmark | ||
| Aalborg Psychiatric Hospital |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 3046553 | Background | Kane J, Honigfeld G, Singer J, Meltzer H. Clozapine for the treatment-resistant schizophrenic. A double-blind comparison with chlorpromazine. Arch Gen Psychiatry. 1988 Sep;45(9):789-96. doi: 10.1001/archpsyc.1988.01800330013001. |
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| ID | Term |
|---|---|
| D012559 | Schizophrenia |
| ID | Term |
|---|---|
| D019967 | Schizophrenia Spectrum and Other Psychotic Disorders |
| D001523 | Mental Disorders |
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| CHEMPAQ | Device | Capillary blood sample analyzed by CHEMPAQ |
|
| Aalborg |
| 9000 |
| Denmark |
| Psychiatric Center Aarhus | Aarhus | 8240 | Denmark |
| Psychiatric Center Copenhagen | Copenhagen | Denmark |
| Psychiatric Centre Esbjerg | Esbjerg | Denmark |
| Psychiatric Center Odense | Odense | 5000 | Denmark |