Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The purpose of this study is to evaluate the efficacy of AC-150 compared to vehicle and its components in the prevention of the signs and symptoms of allergic conjunctivitis in Enviro-CAC™ Model.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| AC-150 Combo | Experimental |
| |
| AC-150A 0.1% | Active Comparator |
| |
| AC-150B 0.005% | Active Comparator |
| |
| Vehicle | Other |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| AC-150 Combo | Drug | 1 drop in each eye for up to 14 days |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Ocular Itching at Onset of Action (15 Minutes Post-dose) | A treatment efficacy CAC was performed 15 minutes after drop instillation. Ocular itching was assessed by the patient on a 0-4 scale (0=none to 4=severe). Average of ocular itching score over both eyes was analyzed. | 3, 5, 7 minutes post-CAC |
| Ocular Itching at Duration of Action (16 Hours Post-dose) | A treatment efficacy CAC was performed 16 hours after drop instillation. Ocular itching was assessed by the patient on a 0-4 scale (0=none to 4=severe). Average of ocular itching score over both eyes was analyzed. | 3, 5, 7 minutes post-CAC |
| Ocular Itching at 8 Hours Post-dose at Visit 4A | A treatment efficacy CAC was performed 8 hours after drop instillation. Ocular itching was assessed by the patient on a 0-4 scale (0=none to 4=severe). Average of ocular itching score over both eyes was analyzed. | 3, 5, 7 minutes post-CAC |
| Conjunctival Redness at Onset of Action (15 Minutes Post-dose) | A treatment efficacy CAC was performed 15 minutes after drop instillation. Conjunctival Redness was assessed by the patient on a 0-4 scale (0=none to 4=severe). Average of conjunctival redness score over both eyes was analyzed. | 7, 15, 20 minutes post-CAC |
| Conjunctival Redness at Duration of Action (16 Hours Post-dose) | A treatment efficacy CAC was performed 16 hours after drop instillation. Conjunctival Redness was assessed by the patient on a 0-4 scale (0=none to 4=severe). Average of conjunctival redness score over both eyes was analyzed. | 7, 15, 20 minutes post-CAC |
| Conjunctival Redness at 8 Hours Post-dose at Visit 4A |
| Measure | Description | Time Frame |
|---|---|---|
| Ciliary Redness at Onset of Action (15 Minutes Post-dose) | A treatment efficacy CAC was performed 15 minutes after drop instillation. Ciliary Redness was assessed by the patient on a 0-4 scale (0=none to 4=severe). Average of ciliary redness score over both eyes was analyzed. | 7, 15, 20 minutes post-CAC |
| Ciliary Redness at Duration of Action (16 Hours Post-dose) |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Gail L Torkildsen, MD | Andover Eye Associates | Principal Investigator |
| Nicholas P Marsico, MD | East West Eye Institute | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ora, Inc | Andover | Massachusetts | 01810 | United States |
There were 83 subjects enrolled, 12 subjects discontinued, and 71 subjects completed the study. Participant flow and baseline characteristics are presented for the 83 subjects that met all inclusion criteria and none of the exclusion criteria and were randomized to receive AC-150 Combo, AC-150A 0.1%, AC-150B 0.005% or Vehicle
Subjects were recruited from two sites in the US.
Not provided
| ID | Title | Description |
|---|---|---|
| FG000 | AC-150 Combo | AC-150 Combo: 1 drop in each eye for up to 14 days |
| FG001 | AC-150A 0.1% | AC-150A 0.1%: 1 drop in each eye once per day for up to 14 days |
| FG002 | AC-150B 0.005% | AC-150B 0.005%: 1 drop in each eye once per day for up to 14 days |
| FG003 | Vehicle | Vehicle: 1 drop in each eye once per day for up to 14 days |
| Title | Milestones | Reasons Not Completed | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
|
Not provided
Not provided
| ID | Title | Description |
|---|---|---|
| BG000 | AC-150 Combo | AC-150 Combo: 1 drop in each eye for up to 14 days |
| BG001 | AC-150A 0.1% | AC-150A 0.1%: 1 drop in each eye once per day for up to 14 days |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Continuous | Mean |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Ocular Itching at Onset of Action (15 Minutes Post-dose) | A treatment efficacy CAC was performed 15 minutes after drop instillation. Ocular itching was assessed by the patient on a 0-4 scale (0=none to 4=severe). Average of ocular itching score over both eyes was analyzed. | Intent to Treat (ITT) | Posted | Mean | Standard Deviation | units on a scale | 3, 5, 7 minutes post-CAC |
|
Adverse events were collected through the completion of the study, approximately two months. All subjects who received study medication were evaluable for the safety analysis.
Throughout the visit, staff collected all Adverse Events reported, elicited or observed.
Not provided
| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | AC-150 Combo | AC-150: 1 drop in each eye for up to 14 days |
Not provided
Not provided
Not provided
| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Michael V.W. Bergamini, PhD - Chief Scientific Officer/Executive Vice President | Nicox Ophthalmics Inc. | 817-529-9315 | bergamini@nicox.com |
Not provided
| ID | Term |
|---|---|
| D003233 | Conjunctivitis, Allergic |
| ID | Term |
|---|---|
| D003231 | Conjunctivitis |
| D003229 | Conjunctival Diseases |
| D005128 | Eye Diseases |
| D006969 | Hypersensitivity, Immediate |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| AC-150A 0.1% |
| Drug |
1 drop in each eye once per day for up to 14 days |
|
| AC-150B 0.005% | Drug | 1 drop in each eye once per day for up to 14 days |
|
| Vehicle | Drug | 1 drop in each eye once per day for up to 14 days |
|
A treatment efficacy CAC was performed 8 hours after drop instillation. Conjunctival Redness was assessed by the patient on a 0-4 scale (0=none to 4=severe). Average of conjunctival redness score over both eyes was analyzed. |
| 7, 15, 20 minutes post-CAC |
A treatment efficacy CAC was performed 16 hours after drop instillation. Ciliary Redness was assessed by the patient on a 0-4 scale (0=none to 4=severe). Average of ciliary redness score over both eyes was analyzed. |
| 7, 15, 20 minutes post-CAC |
| Ciliary Redness at 8 Hours Post-dose at Visit 4A | A treatment efficacy CAC was performed 8 hours after drop instillation. Ciliary Redness was assessed by the patient on a 0-4 scale (0=none to 4=severe). Average of ciliary redness score over both eyes was analyzed. | 7, 15, 20 minutes post-CAC |
| Episcleral Redness at Onset of Action (15 Minutes Post-dose) | A treatment efficacy CAC was performed 15 minutes after drop instillation. Episcleral Redness was assessed by the patient on a 0-4 scale (0=none to 4=severe). Average of episcleral redness score over both eyes was analyzed. | 7, 15, 20 minutes post-CAC |
| Episcleral Redness at Duration of Action (16 Hours Post-dose) | A treatment efficacy CAC was performed 16 hours after drop instillation. Episcleral Redness was assessed by the patient on a 0-4 scale (0=none to 4=severe). Average of Episcleral redness score over both eyes was analyzed. | 7, 15, 20 minutes post-CAC |
| Episcleral Redness at 8 Hours Post-dose at Visit 4A | A treatment efficacy CAC was performed 8 hours after drop instillation. Episcleral Redness was assessed by the patient on a 0-4 scale (0=none to 4=severe). Average of episcleral redness score over both eyes was analyzed. | 7, 15, 20 minutes post-CAC |
| Total Redness at Onset of Action (15 Minutes Post-dose) | A treatment efficacy CAC was performed 15 minutes after drop instillation. Total redness was defined as the sum of the conjunctival, ciliary and episcleral redness scores, and was, thus, on a 0-12 scale, making the threshold for clinical significance a treatment difference of 3.0 units. Higher scores represent greater severity. | 7, 15, 20 minutes post-CAC |
| Total Redness at Duration of Action (16 Hours Post-dose) | A treatment efficacy CAC was performed 16 hours after drop instillation. Total redness was defined as the sum of the conjunctival, ciliary and episcleral redness scores, and was, thus, on a 0-12 scale, making the threshold for clinical significance a treatment difference of 3.0 units. Higher scores represent greater severity. | 7, 15, 20 minutes post-CAC |
| Total Redness at 8 Hours Post-Dose at Visit 4A | A treatment efficacy CAC was performed 8 hours after drop instillation. Total redness was defined as the sum of the conjunctival, ciliary and episcleral redness scores, and was, thus, on a 0-12 scale, making the threshold for clinical significance a treatment difference of 3.0 units. Higher scores represent greater severity. | 7, 15, 20 minutes post-CAC |
| Lid Swelling at Onset of Action (15 Minutes Post-dose) | A treatment efficacy CAC was performed 15 minutes after drop instillation. Lid swelling was assessed by the patient on a 0-3 scale (0=none to 3=severe). Average of lid swelling score over both eyes was analyzed. | 7, 15, 20 minutes post-CAC |
| Lid Swelling Duration of Action (16 Hours Post-dose) | A treatment efficacy CAC was performed 16 hours after drop instillation. Lid swelling was assessed by the patient on a 0-3 scale (0=none to 3=severe). Average of lid swelling score over both eyes was analyzed. | 7, 15, 20 minutes post-CAC |
| Lid Swelling at 8 Hours Post-dose at Visit 4A | A treatment efficacy CAC was performed 8 hours after drop instillation. Lid swelling was assessed by the patient on a 0-3 scale (0=none to 3=severe). Average of lid swelling score over both eyes was analyzed. | 7, 15, 20 minutes post-CAC |
| Ear or Palate Pruritus at Onset of Action (15 Minutes Post-dose) | A treatment efficacy CAC was performed 15 minutes after drop instillation. Ear or Palate Pruritus was assessed by the patient on a single 0-4 scale (0=none to 4=severe). Ear or Palate Pruritus score for each time point was analyzed. | 7, 15, 20 minutes post-CAC |
| Ear or Palate Pruritus at Duration of Action (16 Hours Post-dose) | A treatment efficacy CAC was performed 15 minutes after drop instillation. Ear or Palate Pruritus was assessed by the patient on a single 0-4 scale (0=none to 4=severe). Ear or Palate Pruritus score for each time point was analyzed. | 7, 15, 20 minutes post-CAC |
| Ear or Palate Pruritus at 8 Hours Post-dose at Visit 4A | A treatment efficacy CAC was performed 15 minutes after drop instillation. Ear or Palate Pruritus was assessed by the patient on a single 0-4 scale (0=none to 4=severe). Ear or Palate Pruritus score for each time point was analyzed. | 7, 15, 20 minutes post-CAC |
| Tolerability of Study Medication at Visit 2B | Subjects were asked to rate the comfort of the drop in each eye upon instillation, at 1 minute, and at 2 minutes after instillation of study medication. The assessment used a 10-point scale with 0 as very comfortable and 10 as very uncomfortable. Higher scores represent a worse outcome. | upon instillation, 1 minute and 2 minutes post instillation |
| Tolerability of Study Medication at Visit 3 | Subjects were asked to rate the comfort of the drop in each eye upon instillation, at 1 minute, and at 2 minutes after instillation of study medication. The assessment used a 10-point scale with 0 as very comfortable and 10 as very uncomfortable. Higher scores represent a worse outcome. | upon instillation, 1 minute and 2 minutes post instillation |
| BG002 | AC-150B 0.005% | AC-150B 0.005%: 1 drop in each eye once per day for up to 14 days |
| BG003 | Vehicle | Vehicle: 1 drop in each eye once per day for up to 14 days |
| BG004 | Total | Total of all reporting groups |
| years |
|
| Sex: Female, Male | Count of Participants | Participants |
|
| Ethnicity (NIH/OMB) | Count of Participants | Participants |
|
| Race (NIH/OMB) | Count of Participants | Participants |
|
| Region of Enrollment | Number | participants |
|
| OG002 |
| AC-150B 0.005% |
AC-150B 0.005%: 1 drop in each eye once per day for up to 14 days |
| OG003 | Vehicle | Vehicle: 1 drop in each eye once per day for up to 14 days |
|
|
| Primary | Ocular Itching at Duration of Action (16 Hours Post-dose) | A treatment efficacy CAC was performed 16 hours after drop instillation. Ocular itching was assessed by the patient on a 0-4 scale (0=none to 4=severe). Average of ocular itching score over both eyes was analyzed. | Intent to Treat (ITT) Population with Last Observation Carried Forward (LOCF) | Posted | Mean | Standard Deviation | units on a scale | 3, 5, 7 minutes post-CAC |
|
|
|
| Primary | Ocular Itching at 8 Hours Post-dose at Visit 4A | A treatment efficacy CAC was performed 8 hours after drop instillation. Ocular itching was assessed by the patient on a 0-4 scale (0=none to 4=severe). Average of ocular itching score over both eyes was analyzed. | Intent to Treat (ITT) Population with Last Observation Carried Forward (LOCF) | Posted | Mean | Standard Deviation | units on a scale | 3, 5, 7 minutes post-CAC |
|
|
|
| Primary | Conjunctival Redness at Onset of Action (15 Minutes Post-dose) | A treatment efficacy CAC was performed 15 minutes after drop instillation. Conjunctival Redness was assessed by the patient on a 0-4 scale (0=none to 4=severe). Average of conjunctival redness score over both eyes was analyzed. | Intent to Treat (ITT) Population with Last Observation Carried Forward (LOCF) | Posted | Mean | Standard Deviation | units on a scale | 7, 15, 20 minutes post-CAC |
|
|
|
| Primary | Conjunctival Redness at Duration of Action (16 Hours Post-dose) | A treatment efficacy CAC was performed 16 hours after drop instillation. Conjunctival Redness was assessed by the patient on a 0-4 scale (0=none to 4=severe). Average of conjunctival redness score over both eyes was analyzed. | Intent to Treat (ITT) Population with Last Observation Carried Forward (LOCF) | Posted | Mean | Standard Deviation | units on a scale | 7, 15, 20 minutes post-CAC |
|
|
|
| Primary | Conjunctival Redness at 8 Hours Post-dose at Visit 4A | A treatment efficacy CAC was performed 8 hours after drop instillation. Conjunctival Redness was assessed by the patient on a 0-4 scale (0=none to 4=severe). Average of conjunctival redness score over both eyes was analyzed. | Intent to Treat (ITT) Population with Last Observation Carried Forward (LOCF) | Posted | Mean | Standard Deviation | units on a scale | 7, 15, 20 minutes post-CAC |
|
|
|
| Secondary | Ciliary Redness at Onset of Action (15 Minutes Post-dose) | A treatment efficacy CAC was performed 15 minutes after drop instillation. Ciliary Redness was assessed by the patient on a 0-4 scale (0=none to 4=severe). Average of ciliary redness score over both eyes was analyzed. | Per protocol population | Posted | Mean | Standard Deviation | units on a scale | 7, 15, 20 minutes post-CAC |
|
|
|
| Secondary | Ciliary Redness at Duration of Action (16 Hours Post-dose) | A treatment efficacy CAC was performed 16 hours after drop instillation. Ciliary Redness was assessed by the patient on a 0-4 scale (0=none to 4=severe). Average of ciliary redness score over both eyes was analyzed. | Per protocol population | Posted | Mean | Standard Deviation | units on a scale | 7, 15, 20 minutes post-CAC |
|
|
|
| Secondary | Ciliary Redness at 8 Hours Post-dose at Visit 4A | A treatment efficacy CAC was performed 8 hours after drop instillation. Ciliary Redness was assessed by the patient on a 0-4 scale (0=none to 4=severe). Average of ciliary redness score over both eyes was analyzed. | Per protocol population | Posted | Mean | Standard Deviation | units on a scale | 7, 15, 20 minutes post-CAC |
|
|
|
| Secondary | Episcleral Redness at Onset of Action (15 Minutes Post-dose) | A treatment efficacy CAC was performed 15 minutes after drop instillation. Episcleral Redness was assessed by the patient on a 0-4 scale (0=none to 4=severe). Average of episcleral redness score over both eyes was analyzed. | Per protocol population | Posted | Mean | Standard Deviation | units on a scale | 7, 15, 20 minutes post-CAC |
|
|
|
| Secondary | Episcleral Redness at Duration of Action (16 Hours Post-dose) | A treatment efficacy CAC was performed 16 hours after drop instillation. Episcleral Redness was assessed by the patient on a 0-4 scale (0=none to 4=severe). Average of Episcleral redness score over both eyes was analyzed. | Per protocol population | Posted | Mean | Standard Deviation | units on a scale | 7, 15, 20 minutes post-CAC |
|
|
|
| Secondary | Episcleral Redness at 8 Hours Post-dose at Visit 4A | A treatment efficacy CAC was performed 8 hours after drop instillation. Episcleral Redness was assessed by the patient on a 0-4 scale (0=none to 4=severe). Average of episcleral redness score over both eyes was analyzed. | Per protocol population | Posted | Mean | Standard Deviation | units on a scale | 7, 15, 20 minutes post-CAC |
|
|
|
| Secondary | Total Redness at Onset of Action (15 Minutes Post-dose) | A treatment efficacy CAC was performed 15 minutes after drop instillation. Total redness was defined as the sum of the conjunctival, ciliary and episcleral redness scores, and was, thus, on a 0-12 scale, making the threshold for clinical significance a treatment difference of 3.0 units. Higher scores represent greater severity. | Per protocol population | Posted | Mean | Standard Deviation | units on a scale | 7, 15, 20 minutes post-CAC |
|
|
|
| Secondary | Total Redness at Duration of Action (16 Hours Post-dose) | A treatment efficacy CAC was performed 16 hours after drop instillation. Total redness was defined as the sum of the conjunctival, ciliary and episcleral redness scores, and was, thus, on a 0-12 scale, making the threshold for clinical significance a treatment difference of 3.0 units. Higher scores represent greater severity. | Per protocol population | Posted | Mean | Standard Deviation | units on a scale | 7, 15, 20 minutes post-CAC |
|
|
|
| Secondary | Total Redness at 8 Hours Post-Dose at Visit 4A | A treatment efficacy CAC was performed 8 hours after drop instillation. Total redness was defined as the sum of the conjunctival, ciliary and episcleral redness scores, and was, thus, on a 0-12 scale, making the threshold for clinical significance a treatment difference of 3.0 units. Higher scores represent greater severity. | Per protocol population | Posted | Mean | Standard Deviation | units on a scale | 7, 15, 20 minutes post-CAC |
|
|
|
| Secondary | Lid Swelling at Onset of Action (15 Minutes Post-dose) | A treatment efficacy CAC was performed 15 minutes after drop instillation. Lid swelling was assessed by the patient on a 0-3 scale (0=none to 3=severe). Average of lid swelling score over both eyes was analyzed. | Per protocol population | Posted | Mean | Standard Deviation | units on a scale | 7, 15, 20 minutes post-CAC |
|
|
|
| Secondary | Lid Swelling Duration of Action (16 Hours Post-dose) | A treatment efficacy CAC was performed 16 hours after drop instillation. Lid swelling was assessed by the patient on a 0-3 scale (0=none to 3=severe). Average of lid swelling score over both eyes was analyzed. | Per protocol population | Posted | Mean | Standard Deviation | units on a scale | 7, 15, 20 minutes post-CAC |
|
|
|
| Secondary | Lid Swelling at 8 Hours Post-dose at Visit 4A | A treatment efficacy CAC was performed 8 hours after drop instillation. Lid swelling was assessed by the patient on a 0-3 scale (0=none to 3=severe). Average of lid swelling score over both eyes was analyzed. | Per protocol population | Posted | Mean | Standard Deviation | units on a scale | 7, 15, 20 minutes post-CAC |
|
|
|
| Secondary | Ear or Palate Pruritus at Onset of Action (15 Minutes Post-dose) | A treatment efficacy CAC was performed 15 minutes after drop instillation. Ear or Palate Pruritus was assessed by the patient on a single 0-4 scale (0=none to 4=severe). Ear or Palate Pruritus score for each time point was analyzed. | Per protocol population | Posted | Mean | Standard Deviation | units on a scale | 7, 15, 20 minutes post-CAC |
|
|
|
| Secondary | Ear or Palate Pruritus at Duration of Action (16 Hours Post-dose) | A treatment efficacy CAC was performed 15 minutes after drop instillation. Ear or Palate Pruritus was assessed by the patient on a single 0-4 scale (0=none to 4=severe). Ear or Palate Pruritus score for each time point was analyzed. | Per protocol population | Posted | Mean | Standard Deviation | units on a scale | 7, 15, 20 minutes post-CAC |
|
|
|
| Secondary | Ear or Palate Pruritus at 8 Hours Post-dose at Visit 4A | A treatment efficacy CAC was performed 15 minutes after drop instillation. Ear or Palate Pruritus was assessed by the patient on a single 0-4 scale (0=none to 4=severe). Ear or Palate Pruritus score for each time point was analyzed. | Per protocol population | Posted | Mean | Standard Deviation | units on a scale | 7, 15, 20 minutes post-CAC |
|
|
|
| Secondary | Tolerability of Study Medication at Visit 2B | Subjects were asked to rate the comfort of the drop in each eye upon instillation, at 1 minute, and at 2 minutes after instillation of study medication. The assessment used a 10-point scale with 0 as very comfortable and 10 as very uncomfortable. Higher scores represent a worse outcome. | Intent to Treat (ITT). Number of analyzed subjects differ due to subject discontinuation during the study. | Posted | Mean | Standard Deviation | units on a scale | upon instillation, 1 minute and 2 minutes post instillation |
|
|
|
| Secondary | Tolerability of Study Medication at Visit 3 | Subjects were asked to rate the comfort of the drop in each eye upon instillation, at 1 minute, and at 2 minutes after instillation of study medication. The assessment used a 10-point scale with 0 as very comfortable and 10 as very uncomfortable. Higher scores represent a worse outcome. | Intent to Treat (ITT) | Posted | Mean | Standard Deviation | units on a scale | upon instillation, 1 minute and 2 minutes post instillation |
|
|
|
| 0 |
| 21 |
| 0 |
| 21 |
| EG001 | AC-150A 0.1% | AC-150A: 1 drop in each eye once per day for up to 14 days | 0 | 21 | 0 | 21 |
| EG002 | AC-150B 0.005% | AC-150B: 1 drop in each eye once per day for up to 14 days | 0 | 20 | 0 | 20 |
| EG003 | Vehicle | Vehicle: 1 drop in each eye once per day for up to 14 days | 0 | 21 | 0 | 21 |
Not provided
Not provided
| D006967 |
| Hypersensitivity |
| D007154 | Immune System Diseases |
| 5 minutes post-CAC |
|
| 7 minutes post-CAC |
|
| 5 minutes post-CAC |
|
| 7 minutes post-CAC |
|
| 15 minutes post-CAC |
|
| 20 minutes post-CAC |
|
| 15 minutes post-CAC |
|
| 20 minutes post-CAC |
|
| 15 minutes post-CAC |
|
| 20 minutes post-CAC |
|
| 15 minutes post-CAC |
|
| 20 minutes post-CAC |
|
| 15 minutes post-CAC |
|
| 20 minutes post-CAC |
|
| 15 minutes post-CAC |
|
| 20 minutes post-CAC |
|
| 15 minutes post-CAC |
|
| 20 minutes post-CAC |
|
| 15 minutes post-CAC |
|
| 20 minutes post-CAC |
|
| 15 minutes post-CAC |
|
| 20 minutes post-CAC |
|
| 15 minutes post-CAC |
|
| 20 minutes post-CAC |
|
| 15 minutes post-CAC |
|
| 20 minutes post-CAC |
|
| 15 minutes post-CAC |
|
| 20 minutes post-CAC |
|
| 15 minutes post-CAC |
|
| 20 minutes post-CAC |
|
| 15 minutes post-CAC |
|
| 20 minutes post-CAC |
|
| 15 minutes post-CAC |
|
| 20 minutes post-CAC |
|
| 15 minutes post-CAC |
|
| 20 minutes post-CAC |
|
| 15 minutes post-CAC |
|
| 20 minutes post-CAC |
|
| 15 minutes post-CAC |
|
| 20 minutes post-CAC |
|
| 1 minute post-instillation |
|
| 2 minutes post-instillation |
|
| 1 minute post-instillation |
|
| 2 minutes post-instillation |
|