Pioglitazone in Psoriasis- A Clinical and Molecular Study.

The CLINICAL And MOLECULAR EFFECTS Of An INSULIN SENSITIZING DRUG: 'PIOGLITAZONE'On PSORIASIS TREATMENT

The study will assess the effectiveness of Pioglitazone on cellular and clinical levels in terms of improvement of both skin and systemic manifestations of psoriasis.

The investigators assume that pioglitazone (one of thiazolidinediones readily available in Egypt), can regulate keratinocytes' disordered proliferation observed in psoriasis, in addition to improving the insulin resistance in peripheral tissues observed in many psoriatic patients and causing metabolic syndrome. This will allow to give a safer therapy than the available ones for psoriasis and to treat the patient in a more global perspective.

Inclusion Criteria:

• Age ≥ 18 years and less than 65 years.
• Plaque psoriasis vulgaris ≥ 10% (apart from palmoplantar psoriasis which will be included).

Exclusion Criteria:

• Age less than 18 years and more than 65 years
• Mild psoriasis less than 10% body surface area
• Erythrodermic or pustular psoriasis
• Liver disease, cardiac disease (suspected from history or ECG), or any other major medical disorder detected by history.
• Pregnant and lactating females.