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Malnutrition in children has even more severe consequences on disease course and long-term health than malnutrition in adults. According to prior studies, malnutrition affects about 15-30 % of hospitalized children in Europe (ESPGHAN 2005, Pawellek et al 2008, Joosten and Hulst 2008). However, available criteria for defining malnutrition in paediatric patients are inconsistent, not based on firm evidence, and not generally agreed upon. Current guidelines do not address assessment of and screening for childhood malnutrition. Therefore, a large number of affected children are not adequately diagnosed.
One aim of this study is to assess the prevalence of malnutrition and patients at risk for malnutrition among at least 2700 hospitalized children mainly across Europe. In addition criteria to link anthropometric measurements and the prediction of outcome, i.e. length of hospital stay, shall be established. A further goal then is to establish agreed, evidence-based criteria for malnutrition in children with the purpose of leading to an agreed, evidence-based screening tool for paediatric malnutrition in developed countries. This tool shall include a set of simple questions, based on previously suggested tools. Thereby this study will provide a strong basis for implementing evidence-based nutritional interventions in paediatric patients by harmonisation of diagnostic criteria for childhood malnutrition in developed countries.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| hospitalised children |
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| Measure | Description | Time Frame |
|---|---|---|
| Length of Hospital Stay | Length of Hospital Stay will be compared between malnourished and non malnourished children. | 60 days |
| Measure | Description | Time Frame |
|---|---|---|
| infection as a complication during hospital stay | frequency of infectious complications (number of days with temperature >38,5°C, number of days with days with antibiotic use) | 60 days |
| gastrointestinal complications (vomiting, diarrhoea) |
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Inclusion Criteria:
Exclusion Criteria:
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This study will be performed in hospitalized children attending general paediatric wards. The network comprises at least 13 teams from at least 11 countries. A total of 2700 patients will be recruited.
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| Name | Affiliation | Role |
|---|---|---|
| Berthold Koletzko, Prof | Ludwig-Maximilians - University of Munich | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Children's Hospital Zagreb | Zagreb | Croatia | ||||
| Rigshospitalet, Copenhagen University Hospital |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27099244 | Derived | Chourdakis M, Hecht C, Gerasimidis K, Joosten KF, Karagiozoglou-Lampoudi T, Koetse HA, Ksiazyk J, Lazea C, Shamir R, Szajewska H, Koletzko B, Hulst JM. Malnutrition risk in hospitalized children: use of 3 screening tools in a large European population. Am J Clin Nutr. 2016 May;103(5):1301-10. doi: 10.3945/ajcn.115.110700. Epub 2016 Apr 20. | |
| 24461472 |
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| ID | Term |
|---|---|
| D044342 | Malnutrition |
| ID | Term |
|---|---|
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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frequency of gastrointestinal complications: frequency of vomiting and diarrhoea during hospital stay
| 60 days |
| muscle strength | maximal isometric grip force in children ≥ 6 years of age measured within 24 hours after admission | within 24 hours after admission |
| Copenhagen |
| Denmark |
| Paediatric Clinical Investigation Center Unit (CIC-9301-Inserm-CHU) and U995-Inserm, hospital Jeanne de Flandre, University hospital of Lille. | Lille | France |
| Dr. von Hauner Children's Hospital. Munich, Germany | Munich | Bavaria | 80337 | Germany |
| Technological Education Institute | Thessaloniki | Greece |
| Schneider Children's Hospital | Petah Tikvah | Israel |
| Fondazione IRCCS Cà Granda - Ospedale Maggiore Policlinico - Milano | Milan | Italy |
| Beatrix Children's Hospital, University Medical Center Groningen | Groningen | Netherlands |
| Sophia Children's Hospital, Erasmus University | Rotterdam | Netherlands |
| Medical Univ. of Warsaw | Warsaw | Poland |
| The Children's Memorial Health Institute | Warsaw | Poland |
| Spitalul Clinic da Urgenta pentru Copii | Cluj-Napoca | Romania |
| Oxford Children's Hospital | Oxford | United Kingdom |
| Royal Hospital for Sick Children | Yorkhill Glasgow | United Kingdom |
| Hecht C, Weber M, Grote V, Daskalou E, Dell'Era L, Flynn D, Gerasimidis K, Gottrand F, Hartman C, Hulst J, Joosten K, Karagiozoglou-Lampoudi T, Koetse HA, Kolacek S, Ksiazyk J, Niseteo T, Olszewska K, Pavesi P, Piwowarczyk A, Rousseaux J, Shamir R, Sullivan PB, Szajewska H, Vernon-Roberts A, Koletzko B. Disease associated malnutrition correlates with length of hospital stay in children. Clin Nutr. 2015 Feb;34(1):53-9. doi: 10.1016/j.clnu.2014.01.003. Epub 2014 Jan 11. |