Study of Vitamin D3 Substitution to Patients With Primary Immunodeficiency

A Placebo Controlled Double Blinded Study of Vitamin D3 Substitution to Patients With Primary Immunodeficiency

Hypothesis: Cholecalciferol (vitamin D3) prevent respiratory tract infections in patients with primary immunodeficiency.

Inclusion Criteria:

• Age 18-75
• Increased number of respiratory tract infections
• At least 42 days of infections during 2008 or 2009
• S-25 OH vitamin D3 < 250 nM
• Not planning a pregnancy during the coming year
• Accepting the use of contraceptives during 1 year

Exclusion Criteria:

• Continuous antibiotic treatment
• Hypercalcemia
• Sarcoidosis
• Kidney disease
• Tuberculosis
• Pregnancy
• Kidney stone
• Heart medication (glycosides)