Prevention of Drug Induced Ototoxicity in Peritoneal Dialysis Patients by N-Acetylcysteine

The Evaluation of the Protective Effect of N-Acetylcysteine Against Drug Induced Ototoxicity in Peritoneal Dialysis Patients

The purpose of this study is to determine whether N-acetylcysteine is effective in the prevention of hearing loss in both ears due to aminoglycoside and/or vancomycine induced ototoxicity in peritoneal dialysis patients.

Inclusion Criteria:

• End-stage renal disease
• Undergoing continuous ambulatory peritoneal dialysis as a renal replacement therapy
• Clinical diagnosis of a peritonitis episode in a continuous ambulatory peritoneal dialysis patient
• Developing the first continuous ambulatory peritoneal dialysis related peritonitis episode

Exclusion Criteria:

• Being treated with aminoglycoside antibiotics and vancomycine within the previous 3 months
• Detection of mechanical occlusion of external ear
• Having signs of disturbed integrity of tympanic membrane on otoscopy or tympanometry
• History of a continuous ambulatory peritoneal dialysis related peritonitis