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| Name | Class |
|---|---|
| University of Cincinnati | OTHER |
| Baylor College of Medicine | OTHER |
| Weill Medical College of Cornell University | OTHER |
| University of Iowa |
The investigators study is to investigate safety and efficacy of performing a planned incomplete removal of large acoustic neuroma tumors to decrease surgical morbidity and yet avoid tumor recurrence by post-operative radiation therapy.
The current standard treatment of a large tumor of the balance nerve (acoustic neuroma or vestibular schwannoma) is surgical resection. Complete removal of such tumor is associated with significant risks of hearing loss and facial paralysis whereas incomplete removal of the tumor is associated with significant risks of regrowth. Stereotactic radiation is a well accepted therapy aiming at stopping the growth of smaller acoustic neuromas before their sizes become large enough to cause problems. The purpose of our study is to determine whether the combination of subtotal resection followed by stereotactic radiation of the remnant can control large acoustic neuromas without the significant risks associated with complete resection.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| ANSRS group | Patients qualifying for the study. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Microsurgery | Procedure | Patient would under to total, near-total, or subtotal resection of tumor |
|
| Measure | Description | Time Frame |
|---|---|---|
| Need for stereotactic radiation therapy should tumor remnant grow on annual MRI's | 10 years |
| Measure | Description | Time Frame |
|---|---|---|
| Facial nerve function measured on House-Brackmann scale | 10 y |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with large acoustic neuromas measuring 2.5cm in longest dimension in the cerebellopontine angle.
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| Name | Affiliation | Role |
|---|---|---|
| Ashkan Monfared, MD | George Washington University | Study Director |
| Robert K Jackler, MD | Stanford University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Stanford University School of Medicine | Stanford | California | 94305 | United States | ||
| George Washington University |
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| OTHER |
| University of Texas | OTHER |
| George Washington University | OTHER |
| Indiana University | OTHER |
| Louisiana State University Health Sciences Center in New Orleans | OTHER |
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| Stereotactic radiation therapy | Procedure | Patient who has sign of growth of tumor remnant would undergo this treatment |
|
| Washington D.C. |
| District of Columbia |
| 20037 |
| United States |
| Indiana University | Indianapolis | Indiana | 46202 | United States |
| University of Iowa | Iowa City | Iowa | 52242 | United States |
| Louisiana State University | Baton Rouge | Louisiana | 70808 | United States |
| Weill Cornell Medical College | New York | New York | United States |
| University of Cincinnati | Cincinnati | Ohio | United States |
| University of Texas Southwestern | Dallas | Texas | 75390 | United States |
| Baylor College of Medicine | Houston | Texas | United States |
| ID | Term |
|---|---|
| D009464 | Neuroma, Acoustic |
| ID | Term |
|---|---|
| D009442 | Neurilemmoma |
| D018358 | Neuroendocrine Tumors |
| D017599 | Neuroectodermal Tumors |
| D009373 | Neoplasms, Germ Cell and Embryonal |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D009463 | Neuroma |
| D018317 | Nerve Sheath Neoplasms |
| D009380 | Neoplasms, Nerve Tissue |
| D003390 | Cranial Nerve Neoplasms |
| D009423 | Nervous System Neoplasms |
| D009371 | Neoplasms by Site |
| D010524 | Peripheral Nervous System Neoplasms |
| D000160 | Vestibulocochlear Nerve Diseases |
| D012181 | Retrocochlear Diseases |
| D004427 | Ear Diseases |
| D010038 | Otorhinolaryngologic Diseases |
| D010039 | Otorhinolaryngologic Neoplasms |
| D003389 | Cranial Nerve Diseases |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D008866 | Microsurgery |
| D016634 | Radiosurgery |
| ID | Term |
|---|---|
| D013514 | Surgical Procedures, Operative |
| D008846 | Micromanipulation |
| D008919 | Investigative Techniques |
| D011878 | Radiotherapy |
| D013812 | Therapeutics |
| D013238 | Stereotaxic Techniques |
| D019635 | Neurosurgical Procedures |
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