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Second-meal phenomenon denotes the effect of a prior meal in decreasing the rise in blood glucose after a subsequent meal. This phenomenon occurs in normal subjects while it is not clear whether it is also observed in type 2 diabetic patients. This study aims to define whether the second-meal phenomenon occurs in type 2 diabetic patients. We will also seek for the mechanism.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| study A | post-breakfast meal tolerance test + post-lunch meal tolerance test | ||
| study B | fasting + post-lunch meal tolerance test |
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| Measure | Description | Time Frame |
|---|---|---|
| Area under the curve of plasma glucose after meal | Compare the post-lunch AUC of glucose between two meal tolerance tests(one after having breakfast, one after not having breakfast) | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| the mechanism of second-meal phenomenon | serum FFA, plasma insulin, C-peptide, incretin concentration will be measured | 3 months |
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Inclusion Criteria:
Exclusion Criteria:
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type 2 diabetic patients
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| St. Vincent's hospital | Suwon | Kyounggi-do | 442-723 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19161346 | Background | Jovanovic A, Leverton E, Solanky B, Ravikumar B, Snaar JE, Morris PG, Taylor R. The second-meal phenomenon is associated with enhanced muscle glycogen storage in humans. Clin Sci (Lond). 2009 Jul 2;117(3):119-27. doi: 10.1042/CS20080542. | |
| 19531643 | Background | Bonuccelli S, Muscelli E, Gastaldelli A, Barsotti E, Astiarraga BD, Holst JJ, Mari A, Ferrannini E. Improved tolerance to sequential glucose loading (Staub-Traugott effect): size and mechanisms. Am J Physiol Endocrinol Metab. 2009 Aug;297(2):E532-7. doi: 10.1152/ajpendo.00127.2009. Epub 2009 Jun 16. |
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| ID | Term |
|---|---|
| D003924 | Diabetes Mellitus, Type 2 |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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plasma, serum
| 19366973 | Result | Jovanovic A, Gerrard J, Taylor R. The second-meal phenomenon in type 2 diabetes. Diabetes Care. 2009 Jul;32(7):1199-201. doi: 10.2337/dc08-2196. Epub 2009 Apr 14. |
| 21828339 | Derived | Lee SH, Tura A, Mari A, Ko SH, Kwon HS, Song KH, Yoon KH, Lee KW, Ahn YB. Potentiation of the early-phase insulin response by a prior meal contributes to the second-meal phenomenon in type 2 diabetes. Am J Physiol Endocrinol Metab. 2011 Nov;301(5):E984-90. doi: 10.1152/ajpendo.00244.2011. Epub 2011 Aug 9. |
| D004700 | Endocrine System Diseases |