Exploratory Biomarker Study of Cerebrospinal Fluid in Healthy Volunteers

A Study of the Effects of Sampling Rate on Cerebrospinal Fluid (CSF) Biomarker Levels in Healthy Subjects

The objective of this study is to determine the effects of cerebrospinal fluid sampling rate on biomarker levels of young, healthy volunteers.

Inclusion Criteria:

• Age is between 18 and 50 years, inclusive
• Judged to be in general good health based on medical history, physical exam, neuro exam, vital signs, lab profile and ECG

Exclusion Criteria:

• Positive urine drug screen for drugs of abuse
• History of bleeding disorder or deep vein thrombosis
• History of migraine or other types of headache more than twice/month, history of spinal disc disease or chronic significant low back pain
• Use of blood thinning compounds within 10 days of lumbar drain placement
• Finding on head CT that contraindicates lumbar puncture
• History of spinal surgery
• Use of tobacco/nicotine containing products within 6 month period prior to initial lumbar drain placement