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This study aims to study the impact image guided radiotherapy with Cone beam CT will have on the outcomes(toxicities and response) of head and neck cancer when compared to 3D conformal radiotherapy without CBCT based setup error verification.Also,the various dosimetric variations in Adaptive RT will be studied.
Aims and Objectives
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 3DCRT with EPID | Active Comparator | this patients randomised to this arm will be planned by 3DCRT and during treatment setup error will be identified and corrected by weekly EPID if error >3mm.Weekly CBCT will be done for this arm to note the setup error but will not be corrected. |
|
| IGRT with CBCT | Active Comparator | The patients randomised to this arm will be planned by 3DCRT and set up error during RT will be verified by CBCT and error corrected if >3mm.Weekly EPID will be done for setup error documentation but no correction based on EPID in this arm. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| EPID Verification | Radiation | Set up error verification and correction by EPID |
|
| Measure | Description | Time Frame |
|---|---|---|
| compare the early tumour response between 3DCRT and IGRT in head and neck cancer. | The advent of CBCT has increased the verification of Radiation treatment delivery but whether it leads to significant change in tumour response or toxicities when compared to 3D Conformal Radiotherapy without CBCT verification is not known.This study will give insights into this question. | Assessment at post RT week, 1 month after completion of RT and 6 month after completion of RT. Final assessment of last recruited patient is anticipated to be by AUGUST 2011 |
| Measure | Description | Time Frame |
|---|---|---|
| To assess and compare early and late toxicities between 3DCRT and IGRT in head and neck cancer | Assessment will be done by RTOG scoring criteria | assessment of acute and chronic toxicities of the last recruited patient anticipated to be by March 2011 |
| To find out the different doses received by target and organs at risk during the various phases of adaptive RT. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| BIDHU K MOHANTI, MD | All India Institute of Medical Sciences | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| All India Institute of Medical Sciences | New Delhi | New Delhi | 110029 | India |
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| ID | Term |
|---|---|
| D006258 | Head and Neck Neoplasms |
| D007822 | Laryngeal Neoplasms |
| D000077195 | Squamous Cell Carcinoma of Head and Neck |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D010039 | Otorhinolaryngologic Neoplasms |
| D007818 | Laryngeal Diseases |
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| CBCT verification | Radiation | Setup error verification and correction by CBCT |
|
|
| last measurement by AUG 2011 |
| D012140 |
| Respiratory Tract Diseases |
| D012142 | Respiratory Tract Neoplasms |
| D010038 | Otorhinolaryngologic Diseases |
| D002294 | Carcinoma, Squamous Cell |
| D002277 | Carcinoma |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009370 | Neoplasms by Histologic Type |