Comparison of Fenofibrate and Niacin in Patients With Hypertriglyceridemia and Low High-Density Lipoprotein (HDL)-Cholesterol

The purpose of the study is to compare the efficacy and tolerability of fenofibrate 160 mg and niacin 1500 mg in patients with hypertriglyceridemia and low HDL-cholesterol. The primary end point is the percent change of apoB/A1 and the secondary end points are other lipid parameters and biomarkers.

Inclusion Criteria:

• Triglyceride 150-500 mg/dL and HDL-cholesterol < 45 mg/dL after 8 week dietary run in period
• 20-79 years old

Exclusion Criteria:

• Low-density lipoprotein (LDL)-cholesterol ≥ 130 mg/dL without any lipid-modifying drug
• History of cerebrovascular or cardiovascular diseases
• Creatinine > 2.0 mg/dL
• Transaminase > 2x upper limit of normal
• Gall bladder disease
• Cancer
• Pregnant or breast feeding women
• History of adverse events associated with test drugs