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| ID | Type | Description | Link |
|---|---|---|---|
| CSGA-AA1234-01 | Registry Identifier | 02052009 |
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| Name | Class |
|---|---|
| Centre National de la Recherche Scientifique, France | OTHER |
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The purpose of this study is to observe the influence of carbohydrate-to-fat balance on liking, wanting and food consumption in humans.
16 normal-weight men (age: 23 ± 3 y)had completed a randomized 4-condition crossover study. The sessions differed by the composition of the breakfast which was rich in carbohydrates (HCB), low in carbohydrates (LCB), rich in fat (HFB) and low in fat (LFB). The HCB and HFB contained 2072 kJ, while the LCB and LFB contained 565 kJ. Two hours and 20 min later, energy expenditure (EE) and respiratory quotient (RQ) were measured before olfactory liking for 4 foods items and then ad libitum energy intake (EI) during a snack (sweet and fatty toast) were evaluated.
In accordance with the carbohydrate-based models of feeding, one may expect that food choices as well as "liking" and "wanting" (the two components of the reward system) could be influenced by glycogen stores and the carbohydrate-to-fat balance. More precisely, one may expect that a high fat oxidation rate could increase liking and wanting carbohydrates to replenish glycogen stores and conversely, that a high carbohydrate oxidation rate could produce the reverse. In order to validate this hypothesis, the present study has been conducted to investigate in humans the influence of the carbohydrate-to-fat oxidation ratio on carbohydrate-to-fat selection and the food reward system.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| food preloads | Behavioral | Subjects will eat in the morning during breakfast 300g cottage cheese (627kJ - 147kcal; 13.2g carbohydrate, 0.3g fat, 23g protein) plus, according to the situations, either: 90g sucrose, HCB); 6g aspartame; 40g vegetable oil; 40g paraffin oil. Therefore two breakfast will have the same energy content (2072kJ - 495kcal), as did the other two(565 kJ - 135kcal). |
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| Measure | Description | Time Frame |
|---|---|---|
| Respiratory quotient | Respiratory quotient is the ratio of CO2 production on oxygen consumption measured in the expiratory flow | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| food liking | Food liking is the preference for 4 food items smelt | 6 months |
| food wanting | food wanting is the selection of 4 kind of toasts during a snack |
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Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Luc Penicaud, MD | Centre National de la Recherche Scientifique, France | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre des Sciences du Goût et de l'Alimentation | Dijon | 21000 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21795442 | Derived | Brondel L, Landais L, Romer MA, Holley A, Penicaud L. Substrate oxidation influences liking, wanting, macronutrient selection, and consumption of food in humans. Am J Clin Nutr. 2011 Sep;94(3):775-83. doi: 10.3945/ajcn.111.017319. Epub 2011 Jul 27. |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D004435 | Eating |
| D008660 | Metabolism |
| ID | Term |
|---|---|
| D009747 | Nutritional Physiological Phenomena |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D004068 | Digestive System Physiological Phenomena |
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| 6 months |
| food consumption | is the amount of food eaten during the snack | 6 months |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D055688 | Digestive System and Oral Physiological Phenomena |