CoSeal in Liver and Biliary Surgery in Prevention of Denovo Hepatic Adhesion

Effectiveness and Tolerance of CoSeal in the Prevention of Hepatic Adherences of Novo Post Operational Within the Framework of a Hepatic Surgery of Resection in Two Times for Hepatic Metastases: Study of Phase II/III.

Study of phase II: Clinical study national, exploratory, multicentric, prospective, randomized, as a double blind man evaluating the effectiveness and the tolerance of the treatment by a surgical gel of sealing containing polyethylene glycol in the prevention of operational adherences post.3 Study of phase III: Clinical study national, multicentric, prospective, randomized, controlled, as a double blind man comparing a group controls with a group of patients treated by a surgical gel of sealing containing polyethylene glycol in the prevention of hepatic adherences of novo post operational.

Inclusion Criteria:

• Major patients.
• Hepatic Carriers of metastases.
• Eligible with a procedure of surgical eradication in two brought closer times (time lower than 3 months).
• Strategy validated in multidisciplinary meeting of cancerology.
• Enlightened Assent given and signed before the intervention.

Exclusion Criteria:

• Anaesthetic Counter-indications with a procedure in two times
• Carcinose péritonéale, reached metastatic not éradicable
• Over-sensitiveness or allergy known to polyethylene CoSeal glycol
• Concomitant Use of another antiblocking agent
• Immunodéprimés Patients or taking drugs immunodépresseurs with the long court like the corticosteroids,
• Impossibility of subjecting itself to the medical monitoring imposed by the study for reasons geographical, social, psychic or medical.
• Concomitant Participation in another clinical trial