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To describe the type II diabetes population in primary care with special reference to treatment, other diseases and mortality during the last decade. To test the hypothesis that the type or combination of per oral glucose lowering drugs have different effects on the risk of cardiovascular disease and diabetic complications.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Diabetes type II patients, according to medical records, prescriptions or lab results, followed for >6 months after diagnosis. |
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| Measure | Description | Time Frame |
|---|---|---|
| Composite end-point consisting of Cardiovascular Disease, elective coronary revascularisation and mortality | The endpoints will be extracted from the medical records on one occassion, covering a period of one decade. |
| Measure | Description | Time Frame |
|---|---|---|
| Retinopathy, renal failure, hypoglycaemic episodes, other diabetic complications | The endpoints will be extracted from the medical records on one occasion, covering a period of one decade. | |
| Time from: Metformin (MET) to Insulin (INS) versus Metformin (MET) -> Metformin (MET)+Sulfonylurea (SU) ->Insulin (INS) |
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Inclusion Criteria:
Exclusion Criteria:
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Eligible subjects are all type II diabetes patients, found in medical records at the participating centres. Patient data from the period 1 January 1999 - 31 December 2009 will be included in the observation. To ensure a representative selection of primary care centers, selection of study sites will be based on the following criteria to ensure a representative sample of the Swedish population: a mix of rural and urban areas, public and private care providers, small, mid sized and large primary care centers.
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| Name | Affiliation | Role |
|---|---|---|
| Leif Lohm, MD | AstraZeneca Nordic, Södertälje | Study Director |
| Gunnar Johansson, MD | Uppsala University, Sweden | Principal Investigator |
| Carl Johan Östgren, MD | Ödeshögs VC | Study Chair |
| Johan Sundström, MD PhD | Uppsala University Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Research Site | Uppsala | Sweden |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25589001 | Derived | Grundvold I, Bodegard J, Nilsson PM, Svennblad B, Johansson G, Ostgren CJ, Sundstrom J. Body weight and risk of atrial fibrillation in 7,169 patients with newly diagnosed type 2 diabetes; an observational study. Cardiovasc Diabetol. 2015 Jan 15;14:5. doi: 10.1186/s12933-014-0170-3. | |
| 23625112 | Derived | Sundstrom J, Sheikhi R, Ostgren CJ, Svennblad B, Bodegard J, Nilsson PM, Johansson G. Blood pressure levels and risk of cardiovascular events and mortality in type-2 diabetes: cohort study of 34 009 primary care patients. J Hypertens. 2013 Aug;31(8):1603-10. doi: 10.1097/HJH.0b013e32836123aa. |
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| ID | Term |
|---|---|
| D003924 | Diabetes Mellitus, Type 2 |
| D003920 | Diabetes Mellitus |
| ID | Term |
|---|---|
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
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| The endpoints will be extracted from the medical records on one occasion, covering a period of one decade. |
| Number of consultations in primary care. Number of hospitalisations | The endpoints will be extracted from the medical records on one occasion, covering a period of one decade. |
| 23350893 | Derived | Ostgren CJ, Sundstrom J, Svennblad B, Lohm L, Nilsson PM, Johansson G. Associations of HbA1c and educational level with risk of cardiovascular events in 32,871 drug-treated patients with Type 2 diabetes: a cohort study in primary care. Diabet Med. 2013 May;30(5):e170-7. doi: 10.1111/dme.12145. Epub 2013 Mar 13. |