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| ID | Type | Description | Link |
|---|---|---|---|
| HMS-03 | Other Identifier | Ethics Committee |
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| Name | Class |
|---|---|
| Linnan Klinikka Oy | OTHER |
| MTT Agrifood Research Finland | UNKNOWN |
| Finnish Red Cross Blood Service | OTHER |
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In this study, the effects of dietary intake of cold-pressed turnip rapeseed oil (CTPRO) and milk fat are compared in men with metabolic syndrome having already participated in HMS-02 study.
This open and balanced cross-over study consists of two dietary treatment phases (either Virgino (R) CTPRO or butter) for 6 to 8 weeks. They are separated from each other with an eight-week washout period. At the end of both periods and 12-hour fasting an oral glucose-fat tolerance test is carried out. Except glucose, the test consists cream (after the butter phase) and CTPRO (after the CTPRO phase).
Otherwise, the subjects (n=43) are asked to maintain their normal dietary habits.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Rapeseed oil | Active Comparator |
| |
| Milk fat | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cold-pressed turnip rapeseed oil (CTPRO) | Dietary Supplement |
|
| Measure | Description | Time Frame |
|---|---|---|
| Circulating lipids | At the end of both 6- to 8-week dietary periods, fasting values of circulating lipids including oxidized LDL are determined | 6 to 8 weeks |
| Platelet function | At the end of both 6- to 8-week dietary periods, platelet function is determined | 6 to 8 weeks |
| Glucose tolerance | During a 5-hour oral glucose-fat tolerance test the area under curve of plasma glucose and insulin concentration is determined | 5 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Arterial elasticity | At the end of both 6- to 8-week dietary periods, arterial elasticity is determined | 6 to 8 weeks |
| Serum triglyceride AUC | During a 5-hour oral glucose-fat tolerance test the area under curve of serum triglyceride concentration is determined |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Ari K Palomäki, MD PhD | Central Hospital of Kanta-Häme | Study Director |
| Kalevi Oksanen, MD PhD | Central Hospital of Kanta-Häme | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Linnan Klinikka | Hämeenlinna | 13100 | Finland | |||
| Central Hospital of Kanta-Häme |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29755591 | Derived | Saarinen HJ, Husgafvel S, Pohjantahti-Maaroos H, Wallenius M, Palomaki A. Improved insulin sensitivity and lower postprandial triglyceride concentrations after cold-pressed turnip rapeseed oil compared to cream in patients with metabolic syndrome. Diabetol Metab Syndr. 2018 May 4;10:38. doi: 10.1186/s13098-018-0340-7. eCollection 2018. | |
| 28801309 |
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| ID | Term |
|---|---|
| D024821 | Metabolic Syndrome |
| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
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| milk fat | Dietary Supplement |
|
|
|
| 5 hours |
| Platelet function | During a 5-hour oral glucose-fat tolerance test the platelet function is determined | 5 hours |
| Hämeenlinna |
| 13530 |
| Finland |
| Finnish Red Cross Blood Transfusion Service | Helsinki | 00310 | Finland |
| MTT Agrifood Research Finland | Jokioinen | 31600 | Finland |
| Saarinen HJ, Sittiwet C, Simonen P, Nissinen MJ, Stenman UH, Gylling H, Palomaki A. Determining the mechanisms of dietary turnip rapeseed oil on cholesterol metabolism in men with metabolic syndrome. J Investig Med. 2018 Jan;66(1):11-16. doi: 10.1136/jim-2017-000495. Epub 2017 Aug 11. |
| 21122147 | Derived | Palomaki A, Pohjantahti-Maaroos H, Wallenius M, Kankkunen P, Aro H, Husgafvel S, Pihlava JM, Oksanen K. Effects of dietary cold-pressed turnip rapeseed oil and butter on serum lipids, oxidized LDL and arterial elasticity in men with metabolic syndrome. Lipids Health Dis. 2010 Dec 1;9:137. doi: 10.1186/1476-511X-9-137. |
| D009750 |
| Nutritional and Metabolic Diseases |