Branched-chain Aminoacids in Sleep Apnea Syndromes (ARSAS)

Which Place for Branched-chain Aminoacids in the Treatment of Sleep Apnea Syndromes?

The initial hypothesis is that branched-chain aminoacids (BCAA) administration could be beneficial to patients suffering from sleep apnea syndrome (SAS), the aim of the present work is to verify this hypothesis.

The literature data demonstrate that a BCAA complementation improves the physical performances, protects lean mass and increases VO2 max during training.

We demonstrated earlier that this complementation can cure at less partly the hypoxemia of chronic obstructive pulmonary patients by a stimulation of respiratory centres.

Inclusion Criteria:

• Adult with healthy mind, who has attained his majority, and affiliated to Social Security.
• Patient suffering from SAS confirmed by polysomnography (PSG).
• Written informed consent form signed.

Exclusion Criteria:

• Patients receiving neuroleptics or benzodiazepines and affiliated drugs will not be included in the study.
• Patients suffering for severe SAS : those who have a number of IAH higher than 30 in a validated sleep hour, will be excluded for security reasons.
• Pregnant women, nursing mothers or women susceptible to procreate without efficient contraception.
• Patient presenting hypersensitivity to understudying products and their excipients.