The Role of P-glycoprotein in Sitagliptin Clinical Pharmacology

The Role of P-glycoprotein in Sitagliptin Clinical Pharmacology

The purpose of this study is to determine the pharmacogenetics, pharmacokinetics, and drug-drug interactions of sitagliptin therapy.

Inclusion Criteria:

• Healthy men and women between 21 to 60 years of age will be recruited to participate in this study.
• Subjects will be eligible if metabolic, renal, hepatic, and hematological laboratory tests are within normal limits.

Exclusion Criteria:

• Subjects will be excluded from the study if they have a current or past history of cardiovascular, hepatic, endocrine (e.g., diabetes), renal, pancreatic, gastrointestinal, pulmonary, immunologic, hematologic, or neurologic disease.