Hypertonic Saline (6%) Versus Isotonic Saline (0.9%) in Bronchiectasis

A Randomised Double Blind 13 Week Crossover Trial of Hypertonic Saline (6%) Versus Isotonic Saline (0.9%) in Patients With Bronchiectasis.

The investigators hypothesise that nebulised hypertonic saline (6%) will increase the volume of sputum expectorated over a 24 hour period compared to nebulised isotonic saline (0.9%) in patients with mild to severe stable bronchiectasis.

Inclusion Criteria:

• Non CF Bronchiectasis
• 18-80 years
• FEV1 less than 90%
• Chronic sputum production
• Clinical stable

Exclusion Criteria:

• Intolerance to HTS
• Use of HTSaline or antibiotics 14 days prior to study
• Clinically unstable
• Smokers