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The investigators hypothesise that nebulised hypertonic saline (6%) will increase the volume of sputum expectorated over a 24 hour period compared to nebulised isotonic saline (0.9%) in patients with mild to severe stable bronchiectasis.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Hypertonic saline | Other | Hypertonic saline (6%) nebulised twice a day for 4 weeks. (Randomised crossover trial) | ||
| Isotonic saline | Other | Isotonic Saline (0.9%) nebulised twice a day for 4 weeks. |
| Measure | Description | Time Frame |
|---|---|---|
| 24 hour sputum volume | 24 hour volume sputum | 13 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Pulmonary Function Testing | Spirometry (FEV1 and FVC) will assess the side effects using HTS. | 13 weeks |
| Rheology | Rheology is the measurement of the viscosity and elasticity of sputum (viscoelasticity) and also the thread forming ability of mucus (spinnibility). Rheology will assess the extent to which HTS effect the viscosity of secretions and rehydrates secretions by drawing water into the mucus via osmosis. |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Belfast HSCT | Recruiting | Belfast | Northern Ireland | BT9 7AB | United Kingdom |
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| ID | Term |
|---|---|
| D001987 | Bronchiectasis |
| ID | Term |
|---|---|
| D001982 | Bronchial Diseases |
| D012140 | Respiratory Tract Diseases |
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| ID | Term |
|---|---|
| D012462 | Saline Solution, Hypertonic |
| D012965 | Sodium Chloride |
| ID | Term |
|---|---|
| D006982 | Hypertonic Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |
| D002712 | Chlorides |
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| 13 weeks |
| Adherence | All used and unused vials of the study drug shall be counted. The researcher will review the returned vials (used and unused) along with the patient diary cards, which record information regarding airway clearance and administration of study drug. | 13 weeks |
| Patient Reported Outcomes RSSQ | RSSQ: a signs and symptoms questionnaire used in clinical trials in order to diagnose an exacerbation. | 13 weeks |
| Patient Reported Outcome: Leicester Cough Questionnaire: | Leicester Cough Questionnaire: a valid and reliable health status measure for adults with chronic cough Quality of Life Questionnaire Bronchiectasis (QOL-B), a tool used to evaluate quality of life in patients with bronchiectasis. | 13 weeks |
| Bronchiectasis Qol Questionnaire | Bronchiectasis Qol Questionnaire is a disease specific questionnaire developed to assess disease specific QOL in Bronchiectasis | 13 weeks |
| D006851 |
| Hydrochloric Acid |
| D017606 | Chlorine Compounds |
| D007287 | Inorganic Chemicals |
| D017670 | Sodium Compounds |