In extrahepatic bile duct cancer and pancreatic cancer, we will treat postoperatively with COX2 inhibitor and assess survival rate and recurrent rate.

Patients : total 220 patients

• Extrahepatic bile duct cancer : 55 patients for administration of COX2 55 patients for control group
• Pancreas cancer : 55 patients for administration of COX2 55 patients for control group

Indication

• After operation of extrahepatic bile duct cancer or pancreas cancer
• Age : 19 - 70 years old
• The patients who agree to consent sheet.

Contraindication

• Impossible of administration due to severe postoperative morbidities (bleeding, bowel obstruction, pancreatic fistula, biliary fistula)
• Preexisting heart disease: Ischemic heart disease, Heart failure. Severe uncontrolled hypertension (systolic BP>160)
• Renal insufficiency: CCR < 50 or serum creatinin >3.0
• Hepatic insufficiency: Liver cirrhosis or active hepatitis
• Preexisting allergic reaction history for NSAIDs or Sulfonamide
• Current drug intake: Warfarin. Lithium, Fluconazole, Aspirin, Celecoxib
• Preexisting Asthma. Especially aspirin-sensitive asthma.
• Contraindications to aspirin, clopidogrel or celecoxib
• The patients who refuse trial
• The patients who has Psychogenic problem

Allocation

• We will allocate patients randomly, to administration group or control group

Methods

• From postoperative third day, administration will be started
• celecoxib 200mg bid for 6 months for administration group
• Follow up and assess recurrence rate and survival rate

Inclusion Criteria:

• The patients who underwent operation for extrahepatic bile duct cancer or pancreas cancer
• Between 19 and 70 years old
• Agreed to consent sheet

Exclusion Criteria:

• The patients cannot administration of drug due to severe postoperative morbidities.
• Preexisting heart disease: Ischemic heart disease, Heart failure. Severe uncontrolled hypertension (systolic BP>160)
• Renal insufficiency: CCR < 50 or serum creatinin >3.0
• Hepatic insufficiency: Liver cirrhosis or active hepatitis
• Preexisting allergic reaction history for NSAIDs or Sulfonamide
• Current drug intake: Warfarin. Lithium, Fluconazole, Aspirin, Celecoxib
• Preexisting Asthma. Especially aspirin-sensitive asthma.
• Contraindications to aspirin, clopidogrel or celecoxib
• When patients refused
• Patients has psychological problem