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| Name | Class |
|---|---|
| Sanofi | INDUSTRY |
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Total knee replacement is a frequent procedure in Québec's hospitals and the muscular strength of the quadriceps is the best indicator of the patient's functional recovery post surgery. Thus, the importance of the patient's recovery leads to the evaluation of the influence of the femoral nerve block on the muscle strength.
The purpose of the study is to compare the short term and long term recuperation of the quadriceps' motor strength of after a total knee arthroplasty using different types of analgesics such as the continuous femoral nerve block, the single dose femoral nerve block and the systemic analgesic, a patient controlled analgesic pump.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Continuous femoral block | Active Comparator | Patients receive a continuous femoral block for 48 hours and they have patient controlled analgesics. |
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| Single dose femoral block | Active Comparator | Patients receive a single dose femoral block and have patient controlled analgesics. |
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| Patient controlled analgesics | Active Comparator | Patients do not receive a femoral block. They only have patient controlled analgesics. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 48-hour ropivacaine infusions | Drug | Patients receive 20 ml of ropivacaine 0.5 % pre-operation through femoral block catheter, followed by ropivacaine infusions from 0.1 % to 0.1 ml/kg/hour for 48 hours. |
| Measure | Description | Time Frame |
|---|---|---|
| Quadriceps strength measurement with Cybex machine | Evidence of the influence of the different types of analgesics on the strength of the quadriceps post surgery. Quadriceps strength will be evaluated in open chain and closed chain with the help of the Cybex machine. | 6 weeks after surgery |
| Quadriceps strength measurement with Cybex machine | Evidence of the influence of the different types of analgesics on the strength of the quadriceps post surgery. Quadriceps strength will be evaluated in open chain and closed chain with the help of the Cybex machine. | 6 months after surgery |
| Quadriceps strength measurements with Cybex machine | Evidence of the influence of the different types of analgesics on the strength of the quadriceps post surgery. Quadriceps strength will be evaluated in open chain and closed chain with the help of the Cybex machine. | 12 months after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Overall functional recovery | The overall functional recovery of the patient will be evaluated considering the analgesic type using SF-36 and WOMAC questionnaires. | 6 weeks after surgery |
| Pain score on Visual Analog Scale (VAS) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Stéphane Pelet, MD, PhD | Hôpital Enfant-Jésus | Principal Investigator |
| Michèle Angers, PhD | Hôpital Enfant-Jésus | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHA-Pavillon Enfant-Jésus | Québec | Quebec | G1J 1Z4 | Canada |
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| ID | Term |
|---|---|
| D000077212 | Ropivacaine |
| D000700 | Analgesics |
| ID | Term |
|---|---|
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
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| Single dose ropivacaine | Drug | Patients receive 20 ml of ropivacaine 0.5% pre-operation |
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| Patient controlled analgesics | Drug | Patient controlled analgesics alone, no femoral block |
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Evaluation of the effectiveness of the analgesics on pain with VAS .
| every 6 hour for the 48 hours following surgery |
| Hospital stay length | Evaluation of the hospital stay length after total knee replacement taking into account the different types of analgesics. | 4 to 7 days after surgery |
| Overall functional recovery | The overall functional recovery of the patient will be evaluated considering the analgesic type using SF-36 and WOMAC questionnaires. | 6 months after surgery |
| Overall functional recovery | The overall functional recovery of the patient will be evaluated considering the analgesic type using SF-36 and WOMAC questionnaires. | 12 months after surgery |
| D000588 |
| Amines |
| D018689 | Sensory System Agents |
| D018373 | Peripheral Nervous System Agents |
| D045505 | Physiological Effects of Drugs |
| D020228 | Pharmacologic Actions |
| D020164 | Chemical Actions and Uses |
| D002491 | Central Nervous System Agents |
| D045506 | Therapeutic Uses |