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| ID | Type | Description | Link |
|---|---|---|---|
| MK3134-010 |
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The objective of this study is to test the experimental reproducibility and within-subject variability of qEEG (quantitative electroencephalogram) using two probe compounds: MK3134 and lorazepam.
This study will test the hypothesis that EEG (Electroencephalogram) theta power, averaged across a topographical region of interest is decreased 6 hours after administration of MK3134 compared to placebo.
The objective of this study is to test the experimental reproducibility and within-subject variability of qEEG using two probe compounds: MK3134 and lorazepam.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sequence 1 | Experimental | MK3134-Lorazepam-Placebo-MK3134-Lorazepam |
|
| Sequence 2 | Experimental | MK3134-Lorazepam-Placebo-Lorazepam-MK3134 |
|
| Sequence 3 | Experimental | MK3134-Placebo-Lorazepam-MK3134-Lorazepam |
|
| Sequence 4 | Experimental | MK3134-Placebo-Lorazepam-Lorazepam-MK3134 |
|
| Sequence 5 | Experimental | Lorazepam-Placebo-MK3134-MK3134-Lorazepam |
|
| Sequence 6 |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| MK3134 | Drug | MK3134, 25 mg tablets (5 x 5 mg capsule), orally |
|
| Measure | Description | Time Frame |
|---|---|---|
| EEG (Electroencephalogram) theta power averaged across a topographical region of interest 6 hours after administration of MK3134/placebo | Baseline and 6 hours |
| Measure | Description | Time Frame |
|---|---|---|
| EEG (Electroencephalogram) beta and sigma power averaged across all cortical leads 2 hours after administration of lorazepam/placebo | Baseline and 2 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Medical Monitor | Merck Sharp & Dohme LLC | Study Director |
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| ID | Term |
|---|---|
| D003704 | Dementia |
| ID | Term |
|---|---|
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D019965 | Neurocognitive Disorders |
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| ID | Term |
|---|---|
| D008140 | Lorazepam |
| ID | Term |
|---|---|
| D001570 | Benzodiazepinones |
| D001569 | Benzodiazepines |
| D001552 | Benzazepines |
| D006574 | Heterocyclic Compounds, 2-Ring |
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| Experimental |
Lorazepam-Placebo-MK3134-Lorazepam-MK3134 |
|
| Sequence 7 | Experimental | Lorazepam-MK3134-Placebo-MK3134-Lorazepam |
|
| Sequence 8 | Experimental | Lorazepam-MK3134-Placebo-Lorazepam-MK3134 |
|
| Sequence 9 | Experimental | Placebo-MK3134-Lorazepam-MK3134-Lorazepam |
|
| Sequence 10 | Experimental | Placebo-MK3134-Lorazepam-Lorazepam-MK3134 |
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| Sequence 11 | Experimental | Placebo-Lorazepam-MK3134-MK3134-Lorazepam |
|
| Sequence 12 | Experimental | Placebo-Lorazepam-MK3134-Lorazepam-MK3134 |
|
| Comparator: Lorazepam | Drug | Lorazepam, 2 mg (2 x 1 mg tablet), orally |
|
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| Comparator: Placebo | Drug | Placebo, to match MK3134, and placebo to match Lorazepam |
|
| D001523 | Mental Disorders |
| D000072471 |
| Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |