A Drug-drug Interaction Study to Investigate the Effects of AZD1981 on the Metabolism and Pharmacodynamics of Oral Contraceptives

A Phase I, Double-blind, Randomised, Placebo-controlled, Two-cycle Crossover, Drug-drug Interaction Study to Investigate the Effects of AZD1981 Tablets 400 mg Twice Daily on the PK and PD of Oral Contraceptives in Healthy Female Volunteers

The primary purpose of this study is to determine whether the treatment with AZD1981 will affect the metabolism of hormones included in oral contraceptives.

Inclusion Criteria:

• Females of childbearing potential
• Use of Neovletta or Neovletta 28 minimum 3 months prior to enrolment.
• Willing to use a highly effective method of birth control, ie, double barrier method contraception.

Exclusion Criteria:

• Pregnancy and/or lactation or delivery/abortion within 6 months prior to randomisation.
• Any clinically significant disease or disorder.
• Any clinically relevant abnormal findings in physical examination.