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| Name | Class |
|---|---|
| Top Institute Food and Nutrition | OTHER |
| Maastricht University Medical Center | OTHER |
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The present study is designed to investigate whether timed protein supplementation will increase skeletal muscle mass in the frail elderly population.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Resistance exercise training and protein drink | Experimental |
| |
| Resistance exercise training and placebo drink | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Protein drink | Dietary Supplement | Protein drink twice a day during 6 months. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in skeletal muscle mass | Baseline, 3 months and 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Physical performance | Baseline, 3 months and 6 months | |
| Blood will be collected to assess parameters related to the outcome measures | Baseline, 3 months and 6 months | |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Lisette de Groot, Professor | Wageningen University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Wageningen University | Wageningen | Gelderland | 6703HD | Netherlands |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35264105 | Derived | Dorhout BG, de Groot LCPGM, van Dongen EJI, Doets EL, Haveman-Nies A. Effects and contextual factors of a diet and resistance exercise intervention vary across settings: an overview of three successive ProMuscle interventions. BMC Geriatr. 2022 Mar 9;22(1):189. doi: 10.1186/s12877-021-02733-6. | |
| 24374288 | Derived |
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| ID | Term |
|---|---|
| D055948 | Sarcopenia |
| ID | Term |
|---|---|
| D009133 | Muscular Atrophy |
| D020879 | Neuromuscular Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D055070 | Resistance Training |
| ID | Term |
|---|---|
| D005081 | Exercise Therapy |
| D012046 | Rehabilitation |
| D000359 | Aftercare |
| D003266 | Continuity of Patient Care |
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| Resistance exercise training | Other | Resistance exercise training twice per week during 6 months. |
|
| Placebo drink | Dietary Supplement | Placebo drink twice a day during 6 months. |
|
| Dietary intake |
| Baseline, 3 months and 6 months |
| Physical activity | Baseline, 3 months and 6 months |
| Cognitive performance | Baseline and 6 months |
| Blood pressure | Baseline, 3 months and 6 months |
| van de Rest O, van der Zwaluw NL, Tieland M, Adam JJ, Hiddink GJ, van Loon LJ, de Groot LC. Effect of resistance-type exercise training with or without protein supplementation on cognitive functioning in frail and pre-frail elderly: secondary analysis of a randomized, double-blind, placebo-controlled trial. Mech Ageing Dev. 2014 Mar-Apr;136-137:85-93. doi: 10.1016/j.mad.2013.12.005. Epub 2013 Dec 27. |
| 22770932 | Derived | Tieland M, Dirks ML, van der Zwaluw N, Verdijk LB, van de Rest O, de Groot LC, van Loon LJ. Protein supplementation increases muscle mass gain during prolonged resistance-type exercise training in frail elderly people: a randomized, double-blind, placebo-controlled trial. J Am Med Dir Assoc. 2012 Oct;13(8):713-9. doi: 10.1016/j.jamda.2012.05.020. Epub 2012 Jul 6. |
| D001284 | Atrophy |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012816 | Signs and Symptoms |
| D005791 |
| Patient Care |
| D013812 | Therapeutics |
| D026741 | Physical Therapy Modalities |
| D064797 | Physical Conditioning, Human |
| D015444 | Exercise |
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |