Relevance of Plasma PCSK9 Concentration as a Biomarker in Acute Coronary Syndrome.

Relevance of Plasma PCSK9 Concentration as a Biomarker in Acute Coronary Syndrome.

PCSK9 (Proprotein convertase subtilisin kexin type 9) plays a key role in LDL-cholesterol (LDLC) metabolism by inhibiting LDL receptor (LDLR) at post-transcriptional level. PCSK9 loss of function mutations are associated to decreased LDLC levels and a cardiovascular protection. In this context, the development of pharmacological inhibitors of PCSK9, in association with statins treatment, represents a major therapeutic issue for LDLC modulation. It was previously shown that PCSK9 plasmatic concentration correlated with plasmatic LDLC, TG and glucose concentrations. However, no data are available on predictive value of PCSK9 plasmatic level concerning coronary disease severity.

The main objective of this study is to determine whether plasmatic PCSK9 concentration is linked to coronary damage severity in patients with acute coronary syndrome.

Inclusion criteria:

• more than 18 years old
• Acute coronary syndrome (ST+ or ST-)
• 2 groups of patients: with statin, and without statin treatment

Exclusion criteria:

• Patient who had cancer during the last 5 years or with cancer in progress
• Patient with severe infection in progress
• Hepatic failure (TP<50%)
• Severe kidney failure
• Patient unable to give his consent to the study