The Effect of Milnacipran in Patients With Fibromyalgia

The Effect of Milnacipran or Placebo on Ventricular Lactate Levels and Fibromyalgia Induced "Brain Fog."

Use of the drug Milnacipran will reduce ventricular lactate levels and processing time for completing complex tasks relative to placebo.

Patients with Fibromyalgia will show elevated ventricular lactate levels as measured via magnetic resonance spectroscopy (MRS). Patients treated with Milnacipran will show normalization of ventricular lactate levels compared to those treated with placebo, and will also show normalization of the increased latency to respond to complex reaction time probes compared to those treated with placebo.

Inclusion Criteria:

• Female or male subjects who fulfill the American College of Rheumatology's case definition for Fibromyalgia.
• 18 through 68 years of age

Exclusion Criteria:

• Pregnant or trying to become pregnant
• Taking any other Serotonin Norepinephrine Reuptake Inhibitor (SNRI) or already taking milnacipran
• Patients who do not indicate their pain levels as less than substantial despite their best care
• History of any psychotic disorder or history of alcoholism or drug abuse within 10 years of intake as determined by psychiatric diagnostic interview
• Presence of current depression as determined by psychiatric diagnostic interview
• Presence of brain lesion on MRI anatomical study